Lilly
Healthcare
SyntheticChemistHighPotencyLab
“Synthetic Chemist High Potency Lab at Lilly. Skills: synthetic chemistry, high potency molecules, process development, manufacturing. synthetically evaluating and facilitating the transfer of chemical processes for highly potent molecules. performing synthetic chemistry and assessing synthetic routes”
What You'll Achieve.
optimize manufacturing processes; increase capacity for clinical trial medicines; reducing costs and environmental impact; translates API/DS process knowledge into clinical supply readiness; oversees technology transfer; implements phase-appropriate control strategies; ensures right-first-time clinical manufacturing; aligns with corporate and Lilly Research Labs (LRL) goals; propels the site toward long-term business success; enable operational readiness; support the project delivery; build the site culture; successful transition to early-phase cGMP manufacturing of grams to kilogram quantities of API required for clinical trial supply; ensure plant readiness of process steps; confirm plant readiness
Industry & Context.
Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges
Limited domestic and international travel (< 5%) may be required, Ability to work in manufacturing and laboratory environments
What They're Looking For.
Must Have
B.S. or M.S. in chemistry, chemical engineering, or related field, 3+ years of experience in synthetic chemistry and/or manufacturing environments involving synthetic small molecule API or drug substance
Nice to Have
High potency chemical synthesis is preferred, Working knowledge of organic chemistry and mechanisms and application to reaction improvement and optimization, Experience with synthetic chemistry techniques used for developing and scaling-up chemical reactions, Experience using process chemistry concepts is a plus, Proficiency with the purification of chemicals via extraction, crystallization, chromatography, and distillation, Comfortable working with larger sized glass equipment, Highly motivated, able to learn rapidly, and demonstrates attention to detail, Has experience creating batch records and conducting scale-up experiments according to those records, Ability to prioritize multiple activities and manage ambiguity, Experience with a variety of analytical techniques: HPLC/UPLC, LC-MS, GC, NMR, IR, KF, XRPD, etc., Process quantification and acquiring mass balance for products and by-products, Demonstrated ability to drive projects and accept change, Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams, Familiarity with crystallization and understanding of polymorphism and particle size control, and safe handling of solids/dry end processing, Problem-solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges, Ability to work cross-functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives
What You'll Do.
synthetically evaluating and facilitating the transfer of chemical processes for highly potent molecules
performing synthetic chemistry and assessing synthetic routes
evaluating the safety of incoming procedures
ordering and staging chemicals
obtaining reference materials
participating in setting up analytical methods
reprocessing and analyzing analytical data
summarizing and presenting chemistry and challenges
performing familiarization reactions
performing use-tests of key raw materials
documenting Definitive Lab Trials of processes
maintaining a well-organized and detailed lab notebook
authoring and reviewing technical documents
applying scientific knowledge to identify areas for improvement
implementing new technologies or procedures
contributing to process troubleshooting and investigations
supporting process deviations
collaborating to perform root cause analysis (RCA) and develop effective corrective and preventive actions (CAPAs)
How You'll Work.
Team & Collaboration
cross-functional collaboration; collaboration with the safety group and process engineering; collaborate with teams to perform root cause analysis (RCA); work cross-functionally across disciplines and levels with engineers, analytical chemists, chemical technicians, safety and quality representatives
Communication Scope
Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams
Process & Methodology
project delivery, drive projects
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