Twist Bioscience
SrScientist,AntibodyDiscovery
Neural analysis suggests this role is
optimal for Senior candidates.
“Sr Scientist, Antibody Discovery at Twist Bioscience. Skills: Antibody discovery, Antibody characterization, Assay development, SPR, BLI. Analyze workflows. Optimize workflows”
Industry & Context.
Troubleshoot scientific processes; Problem-solving mentality
What They're Looking For.
Must Have
PhD in related technical field, 5+ years biopharmaceutical analytical development, Master's in related technical field, 10+ years biopharmaceutical analytical development, Expert knowledge antibody biologics characterization assays, Extensive hands-on experience Carterra SPR, Extensive hands-on experience Octet BLI, Extensive hands-on experience ELISA, Extensive hands-on experience flow cytometry, Extensive hands-on experience antibody developability characterization, Advanced understanding in vivo antibody discovery concepts, Track record developing assay formats, Track record executing assay formats, Track record analyzing assay formats, High-throughput screening experience, Epitope binning experience, Ligand blocking analysis experience, Affinity analysis experience, Cell-based functional assays experience, Demonstrated capability work autonomously, Prioritizing responsibilities high-pressure setting, Proven ability assess scientific data, Proven ability interpret scientific data, Proven ability present scientific data, Exceptional written communication skills, Exceptional verbal communication skills, External customer-facing communication skills, Highly organized, Detail-oriented, Problem-solving mentality
Nice to Have
Experience high-throughput assays, Troubleshoot scientific processes, Make sound scientific decisions, Accurately analyze data, Accurately report data, Work simultaneously multiple workflows, Prioritizing effectively, Effectively communicate project updates, Effectively communicate project risks, Effectively communicate project progress, Actively participate team meetings, Clearly articulating needs, Clearly articulating concerns, Clearly articulating proposed solutions
What You'll Do.
Troubleshoot workflows
Guide multiple projects
Ensure scientific excellence
Ensure scientific execution
Determine binding affinity
Perform developability assays
Assist cross-functionally wet lab teams
Assist Project Management team
Assist scientific leaders
Ensure exquisite project execution
Provide guidance assay integration
Provide guidance assay improvement
Provide technical guidance antibody projects
Develop high-throughput ELISA
Develop kinetic assays
Develop developability assays
Develop advanced characterization
Develop custom characterization
Develop functional screening
Serve end-to-end technical lead
Contribute scientific planning
Contribute feasibility review
Critically analyze data
Present data customers
Communicate timelines
Communicate deliverables
Perform wet-lab benchwork
How You'll Work.
Team & Collaboration
Cross-functional teams; Scientific teams; Wet lab teams; Project Management team; Scientific leaders; Internal stakeholders; External stakeholders; Customers; Manager; Cross-functional team members
Communication Scope
Data presentation; Customer-facing communication
Process & Methodology
Project Lead
Full Job Description
Sr Scientist, Antibody Discovery (onsite in Quincy, MA) Job Description This is an individual contributor role that provides support for bioanalytical characterization for a variety of assays critical for characterizing therapeutic antibody candidates. This role will work closely with our Antibody Characterization and Protein Analytics team at our Quincy, MA location and is responsible for analyzing, optimizing, and troubleshooting a range of workflows, including SPR and BLI affinity analysis, developability assays, flow cytometry, functional assays, and target binding characterization. What You’ll Be Doing: As an individual contributor Senior Scientist, you will support members of multiple scientific teams as a Project Lead, but will not directly manage team members. Guide multiple projects per day to ensure scientific excellence and execution for antibody projects involving binding affinity determination (SPR, BLI) and developability assays (i. e. aSEC, CIC, HIC, BVP-ELISA, AC-SINS, plate-based off-target assays, DLS, and nanoDSF) for a variety of antibody and biologics formats (IgG, VHH, Minibinders, etc.) Assist cross-functionally with the wet lab teams, Project Management team and scientific leaders across multiple sites within the company to ensure exquisite execution of individual projects, while also providing guidance for future assay integration and improvement in the antibody discovery workflow. Provide technical guidance (assay development, analysis, and data reporting) for antibody-based projects in a range of areas, including high-throughput ELISA, flow cytometry, kinetic assays (BLI and SPR), developability assays, advanced/custom characterization, and functional screening. Serve as an end-to-end technical lead for a variety of in vivo antibody discovery programs and contract services, contributing to scientific planning and feasibility review during project scoping. Review, critically analyze, and present data to customers for a variety of concurrent
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