Personalis, Inc.
genomics
Sr.BioinformaticsScientist-DNATechnologyDevelopment&AppliedAI
Neural analysis suggests this role is
optimal for Senior candidates.
“Sr. Bioinformatics Scientist - DNA Technology Development & Applied AI at Personalis, Inc.. Skills: Bioinformatics, DNA Technology Development, Applied AI, genomics, cancer genomics, liquid biopsy, LLMs, deep learning. Design, develop, and build upon our novel cell-free platforms and products, including our NeXT Personal MRD liquid biopsy platform, with a focus on maximizing signal from complex genomic architecture.. Explore and train Large Language Models (LLMs) and foundation models on high-th”
What You'll Achieve.
profiling MRD, ctDNA dynamics, and patient response to treatment; enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples; demonstrating feature performance and clinical advantages of our cell-free platforms; generate biological insights
Industry & Context.
maximizing signal from complex genomic architecture; enhance variant detection; extract novel biological features; generate biological insights
What They're Looking For.
Must Have
Advanced degree (Ph. D. ) in bioinformatics, computational biology, genomics, machine learning or a related field, Extensive experience with cancer genomics including a deep understanding of tumor evolution, mutational signatures, and structural variation., Extensive experience with somatic mutational detection and filtering, Experience with cancer liquid biopsy analysis, Proficiency with at least one common programming language (e. g. , Python, R), A track record of designing and implementing experimental approaches to confirm and elaborate upon findings from complex projects, Experience publishing and presenting scientific results
Nice to Have
utilizing and training modern deep learning architectures, with a preference for candidates who have trained or fine-tuned Large Language Models (LLMs) to decode complex sequences.
What You'll Do.
and build upon our novel cell-free platforms and products
including our NeXT Personal MRD liquid biopsy platform
with a focus on maximizing signal from complex genomic architecture.
Explore and train Large Language Models (LLMs) and foundation models on high-throughput genomic data to enhance variant detection and extract novel biological features.
Design and execute scientific projects and experiments focused on product feature feasibility
demonstrating feature performance and clinical advantages of our cell-free platforms
Modeling and analysis of large
complex genomics datasets using novel methods to generate biological insights
Publish results and present at conferences in exciting areas
including cell-free DNA and cancer genomics
How You'll Work.
Team & Collaboration
work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists; Work cross-functionally to translate collaborative findings into actively developed cutting-edge products; Work with scientific teams to translate scientific findings into actively developed groundbreaking products
Communication Scope
Publish results and present at conferences
Process & Methodology
Design and execute scientific projects and experiments
Full Job Description
Personalis, Inc. is a leader in advanced genomics for precision oncology. NeXT Personal is an ultra-sensitive, tumor-informed, WGS-based liquid biopsy assay designed to detect minimal residual disease (MRD) and cancer recurrence. It leverages whole-genome sequencing of a patient's tumor and matched normal samples to create personalized panel of up to 1,800 somatic variants, enabling the detection of circulating tumor DNA (ctDNA) at very low levels (down to ~1-3 PPM) in blood samples. To enable cancer and population sequencing, Personalis' Clinical Laboratory was built with a focus on clinical accuracy, quality, big data, scale, and efficiency. Personalis is based in Fremont, California. Days Onsite: Monday & Tuesday Summary: The Bioinformatics Senior Scientist will work with a world-class, dynamic team of bioinformatics scientists, software engineers, and laboratory scientists, developing, testing, and applying cutting-edge cell-free and solid tumor cancer genomics products. Further, the Bioinformatics Scientist will be working alongside our clinical evidence generation teams, applying our cell-free solutions to large cancer patient cohorts and profiling patient response to therapy with our cfDNA platforms. This position will directly contribute to a new generation of genomics-based precision-medicine products for profiling MRD, ctDNA dynamics, and patient response to treatment. Our products are used by pharma, biotech, hospitals, and clinicians for managing patient treatment and therapeutic selection. Responsibilities: Design, develop, and build upon our novel cell-free platforms and products, including our NeXT Personal MRD liquid biopsy platform, with a focus on maximizing signal from complex genomic architecture. Explore and train Large Language Models (LLMs) and foundation models on high- throughput genomic data to enhance variant detection and extract novel biological features. Work cross-functionally to translate collaborative findings into actively developed
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