AstraZeneca
biopharmaceutical
SeniorScientist,TranslationalPKPDModeling&DMPK(Oncology)
“Senior Scientist, Translational PKPD Modeling & DMPK (Oncology) at AstraZeneca. Skills: PKPD modeling, DMPK science, Translational PKPD Modeling. Provide projects with specialist modeling input into exploring the PK/PD/Efficacy in pre-clinical models. Use models to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents”
What You'll Achieve.
impact the lives of patients; turns ideas into life changing medicines; advance our understanding of cancer biology; accelerate drug discovery; launch excellence; commercial effectiveness; maximising the lifecycle; change the practice of medicine; redefine cancer treatment
Industry & Context.
collaborative problem-solving
What They're Looking For.
Must Have
Ph. D. in Modeling & Simulation, systems biology, quantitative pharmacology, pharmacometrics, (chemical) engineering, physics, pharmaceutical sciences, or applied mathematics, Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting, Experience in a project-facing role within pharmaceutical R&D, understanding of DMPK and pharmacology in drug discovery
What You'll Do.
Provide projects with specialist modeling input into exploring the PK/PD/Efficacy in pre-clinical models
Use models to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents
Represent Oncology DMPK
providing scientific leadership in cross-functional and external collaborations
Develop and utilize PKPD models to explore the effects of target and pathway modulation
defining candidate drug target profiles
Predict human dose and regimen
contributing to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials
Drive learning through back-translation of clinical exposure and pharmacodynamic data
offering strategic options for future clinical testing
Present findings through publications
enhancing the visibility of AstraZeneca’s translational research
How You'll Work.
Team & Collaboration
scientific leadership in cross-functional and external collaborations; collaborative problem-solving
Communication Scope
Excellent interpersonal, communication, and leadership skills
Applying for this Senior Scientist, Translational PKPD Modeling & DMPK (Oncology) role?
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