Flagship Pioneering, Inc.
Biotechnology
SeniorScientist,TherapeuticsEngineering
Neural analysis suggests this role is
optimal for Senior candidates.
“Senior Scientist, Therapeutics Engineering at Flagship Pioneering, Inc.. Skills: Therapeutics Engineering, Cellular assays, Molecular biology, Gene editing. Conduct cellular screening assays. Optimize cellular screening assays”
What You'll Achieve.
Treat a variety of diseases; Bring novel medicines to patients; Product generation engine
Industry & Context.
Proactively troubleshoot assays; Analyze assay data; Interpret assay data
What They're Looking For.
Must Have
PhD in Cell or Molecular Biology, Biochemistry, or related disciplines, 2+ years relevant experience in biotech or pharma, Hands-on experience in cell-based assays, Hands-on experience in library screening assays, Extensive experience in gene design, Extensive experience in vector construction, Extensive experience in protein expression, Possession of communication skills, both written and verbal
Nice to Have
Industry experience in drug discovery, Industry experience in pharmaceutical R&D
What You'll Do.
Conduct cellular screening assays
Optimize cellular screening assays
Troubleshoot cellular screening assays
Expression characterization of biologics
Functional characterization of biologics
Drive development of cutting-edge assays
Pilot development of cutting-edge assays
Oversee development of cutting-edge assays
Design combinatorial libraries
Procurement combinatorial libraries
Maintenance combinatorial libraries
Identification of external partners
Management of external partners
Execute molecular biology techniques
Culture mammalian cell lines
Maintain mammalian cell lines
Maintain laboratory notebooks
Communicate results in team meetings
Drive optimization of screening protocols
Drive automation of screening protocols
Develop DNA assets for molecular library design
How You'll Work.
Team & Collaboration
Cross-functional scientific team; Close-knit team; Experimental scientists; Computational scientists
Communication Scope
Communicate results clearly; Written communication; Verbal communication; Convey results; Convey scientific data
Full Job Description
About FL114: FL114 is an innovative, privately held biotechnology company developing our novel epigenetic editing platform to treat a variety of diseases through precise, tunable modification of gene expression. FL114 was founded by Flagship Pioneering, where companies such as Moderna Therapeutics (NASDAQ: MRNA) and Seres Therapeutics (NASDAQ: MCRB) were conceived and created. With a strong emphasis on innovation and experimental execution, FL114 cultivates a highly dynamic and entrepreneurial environment. About the Role: FL114, Inc. is seeking a Senior Scientist to join our integrated Platform as a key contributor in our Therapeutics Engineering efforts. The successful candidate will be an essential member of a close-knit team of experimental and computational scientists driving FL114’s product generation engine and supporting a broad set of therapeutic programs. We are looking for enthusiastic, detail-oriented, adaptive, and highly motivated individuals with a passion for bringing novel medicines to patients. Applicants should be comfortable working on a fast-paced, cross-functional scientific team. Key Responsibilities: Independently conduct, optimize and proactively troubleshoot cellular screening assays in a wide range of primary and transformed cell lines. Expression and functional characterization of novel biologics modalities using various cell systems and techniques (cell-based assays, RNA/DNA/protein isolation and detection techniques, RT-qPCR, flow cytometry, etc.) Drive, pilot, and oversee development of a wide range of cutting-edge assays. Design, procurement, and maintenance of combinatorial libraries for relevant cell-based and cell-free assays. Identification and management of external partners (CROs, CMOs, etc). Required Skills: Execute routine and advanced molecular biology techniques, including plasmid preparation, RT-qPCR, cloning, RNA/DNA extraction, gel electrophoresis, oligo pool work, etc. Culture and maintain a wide variety of mammalian cell
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