Amgen
biotech
SeniorScientist-TargetDiscovery&Validation–InducedProximityPlatform(IPP)
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“Senior Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP) at Amgen. Skills: Target Discovery & Validation, Induced Proximity Platform (IPP), discovery biology, proteomics, flow cytometry, multispecific therapeutic development. lead and support cell surface target discovery, validation, and functionalization efforts by developing and applying innovative in vitro assays, proteomics workflows, and flow cytometry based approaches. contribute to large molecule multispecific ”
What You'll Achieve.
uncover novel therapeutic targets; target validation and nomination studies; developing multispecific antibody therapeutics
Industry & Context.
What They're Looking For.
Must Have
Doctorate degree, Master’s degree and 2 years of relevant scientific experience, Bachelor’s degree and 4 years of relevant scientific experience
Nice to Have
Expertise in proximity labeling proteomics platforms and target validation using flow cytometry, biochemical and imaging-based techniques., Experience in cell line generation and overexpression systems (e. g. , lentiviral delivery)., Experience with antibody therapeutics and functional validation of targets using cell-based assays., Hands on experience with cloning, expression and purification analysis is a plus., Familiarity with high-throughput automation platforms (e. g. , Agilent Bravo), high-content imaging platforms and analysis software., Track record of scientific innovation, publications, and/or conference presentations., Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams., Excellent verbal, written, and organizational skills.
What You'll Do.
lead and support cell surface target discovery
and functionalization efforts by developing and applying innovative in vitro assays
and flow cytometry based approaches
contribute to large molecule multispecific therapeutic development through target validation
and execute complex experimental workflows to profile and validate cell surface proteins
Lead and support cell surface-based target discovery and validation projects using in vitro models (cell lines
Apply proximity labeling
cell surface enrichment
and related proteomics efforts for target validation and nomination studies
Support target functionalization efforts toward developing multispecific antibody therapeutics
mechanism of action (MoA) and drug response studies for these therapeutics
Use cutting-edge software tools and collaborate with bioinformatics to analyze and interpret target discovery proteomics datasets
Maintain detailed electronic lab notebooks and experimental records
How You'll Work.
Team & Collaboration
collaborating across multidisciplinary teams to analyze data, communicate findings, and maintain high-quality experimental documentation; Collaborate across multidisciplinary teams to drive integrated target discovery, validation and functionalization efforts; Demonstrated ability to work collaboratively in fast-paced, multidisciplinary teams
Communication Scope
communicate findings; Excellent verbal, written, and organizational skills
Full Job Description
## **Career Category** Scientific ## ## **Job Description** ## Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. **Role: Senior Scientist - Target Discovery & Validation – Induced Proximity Platform (IPP)** Reports to: Principal Scientist Location: Burnaby, BC **What You Will Do** Let’s do this. Let’s change the world. Amgen is seeking a passionate and innovative Scientist to join the **Induced Proximity Platform** team in Burnaby. This role is at the frontier of **discovery biology, combining induced proximity technologies to uncover novel therapeutic targets across Amgen’s key therapeutic areas** including Oncology, Inflammation, and Cardiometabolic diseases The successful candidate will lead and support cell surface target discovery, validation, and functionalization efforts by developing and applying innovative in vitro assays, proteomics workflows, and flow cytometry based approaches. This role will contribute to large m
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