Take Care Of Others

Biotech

SeniorScientist,StemCellModelEngineering

$116–156k Canada FULL TIME
Market Sentiment
HIGH DEMAND

Neural analysis suggests this role is
optimal for Senior candidates.

The Brief

“Senior Scientist, Stem Cell Model Engineering at Take Care Of Others. Skills: Stem Cell Model Engineering, CRISPR, iPSC models. Develop genetically defined iPSC model systems. Define and interpret validation strategies”

What You'll Achieve.

Support target discovery; Support target validation; Support mechanism-of-action studies

Industry & Context.

Biotech
Problems you'll solve

Troubleshoot complex systems; Identify, troubleshoot, and solve technical and biological failure modes

What They're Looking For.

Must Have

PhD in a related discipline with 2+ years of experience, MSc with 5+ years of experience, BSc with 8+ years of experience

Nice to Have

PhD with 2+ years of postdoctoral and/or industry experience in stem cell biology, molecular biology, cell engineering, genetics, developmental biology, bioengineering, or a related discipline, Demonstrated hands-on experience generating CRISPR edited human iPSC models or other difficult-to-engineer human cellular model systems, experimental judgment in genome-engineering strategy, model design, validation requirements, and interpretation of engineered cell model data, Practical understanding of common failure modes in engineered iPSC models, including clonal artifacts, unintended genetic changes, expression instability, differentiation issues, and loss of engineered behavior, Demonstrated scientific productivity and technical credibility through peer-reviewed publications and patents, communication and collaboration skills and ability to work effectively as part of a multidisciplinary team

What You'll Do.

Develop genetically defined iPSC model systems

Define and interpret validation strategies

Solve technical and biological failure modes

Improve current workflows

Drive innovation in stem cell model engineering

How You'll Work.

Team & Collaboration

Work effectively as part of a multidisciplinary team

Communication Scope

Communicate technical risks, timelines, decision points, and model readiness clearly through written and oral presentations

Full Job Description

## **Career Category** Scientific ## ## **Job Description** ## Join Amgen’s Mission of Serving Patients At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. **Sr. Scientist , Stem Cell Model Engineering** **What you will do** Let’s do this. Let’s change the world. In this vital role, you will join the Predictive Biology team as a hands-on scientist focused on building genetically engineered human induced pluripotent stem cell (iPSC) models to support target discovery, target validation, and mechanism-of-action studies. You will troubleshoot complex systems, improve current workflows, and help drive the next wave of innovation in human stem cell model engineering. _Key Responsibilities_ · Develop genetically defined iPSC model systems, including reporter, tagged, loss-of-function, disease-relevant, inducible, or otherwise perturbable models. · Define and interpret fit-for-purpose validation strategies to determine whether engineered models are suitable for downstream bi

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