Evotec
Biotech
SeniorScientistProteinExpression&Automation
Neural analysis suggests this role is
optimal for Senior candidates.
“Senior Scientist Protein Expression & Automation at Evotec. Skills: Protein expression, Automation, Biochemistry. Design protein expression workflows. Optimise protein expression workflows”
What You'll Achieve.
Deliver high-quality protein; Deliver high-quality data; Advance platform capabilities; Advance scientific excellence; Increase throughput; Increase robustness; Increase reproducibility; Improve workflows
Industry & Context.
Problem-solving; Troubleshoot complex expression challenges; Successful problem-solving
What They're Looking For.
Must Have
Extensive experience in recombinant protein expression, Experience in E. coli systems, Experience in mammalian systems, Experience in insect systems, Optimising expression of difficult targets, High-throughput expression workflows, Automation platforms, Molecular biology techniques, Cloning, Construct design, Vector systems, Design and optimise workflows, Problem-solving skills, Troubleshoot complex expression challenges, Delivering results in fast-paced environments, Experience with bioreactor systems, Knowledge of cell line development, Scale-up strategies, Programming/scripting skills, Experience with LIMS, Digital lab infrastructure, Use of in silico tools, Construct design, Expression optimisation, Preparing and executing workplans, Building trusted partnership, Track record of leading scientists, Track record of facilitating employee growth, Co-development of personal development plans, Track record of successful problem-solving
Nice to Have
Familiarity with cell-free expression systems, Experience with Wave bioreactors, Fed-batch optimisation
What You'll Do.
Design protein expression workflows
Optimise protein expression workflows
Execute protein expression workflows
Develop high-throughput screening strategies
Implement high-throughput screening strategies
Optimise expression for challenging targets
Integrate expression workflows
Integrate purification pipelines
Integrate characterisation pipelines
Lead development of automated workflows
Screen small-scale expression
Utilise automation platforms
Develop automation platforms
Increase reproducibility
Drive continuous improvement
Miniaturise workflows
Standardise workflows
Contribute to digital lab initiatives
Ensure data traceability
Apply programming for data analysis
Apply scripting for data analysis
Apply programming for automation
Apply scripting for automation
Apply programming for optimisation
Apply scripting for optimisation
Design expression analytics
Implement expression analytics
Ensure high-quality data generation
Ensure reproducible data generation
Ensure accurate documentation
Lead multiple projects
Contribute to multiple projects
Mentor junior scientists
Contribute to team development
Communicate scientific findings
Represent company at conferences
Present scientific findings
Publish scientific findings
How You'll Work.
Team & Collaboration
Internal stakeholders; External partners; Cross-functional teams; Employee growth; Personal development plans
Communication Scope
Communicate scientific findings; Scientific findings; Scientific reputation
Process & Methodology
Manage priorities, Manage timelines
Full Job Description
We are seeking a highly skilled and innovative Senior Scientist to join our Protein Biochemistry team, with a primary focus on protein expression and automation at scale. This role requires deep expertise in _E. coli_ , mammalian, and insect (baculovirus) expression systems, including expression optimization of complex and challenging targets. You will play a key role in designing, implementing, and scaling automated expression platforms, while ensuring delivery of high-quality protein and data to support drug discovery programs. Through hands-on scientific leadership, you will drive multiple projects simultaneously and contribute to advancing both platform capabilities and scientific excellence **Job Title:** Senior Scientist Protein Expression & Automation **Job Type:** Permanent **Location:**[Alderley Park](http://www.alderleypark.co.uk/), Macclesfield, SK10 4TG **Our Company** Evotec is a leader in the discovery and development of novel small molecule drugs with operational sites in Europe and the US. The Company has built substantial drug discovery expertise and an industrialised platform that can drive new innovative small molecule compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to neuroscience, pain, oncology, inflammation and metabolic diseases. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies **Key Accountabilities** * Design, optimise, and execute protein expression workflows across multiple host systems (_E. coli_ , mammalian, insect). * Develop and implement high-throughput expression screening strategies to enable rapid construct evaluation. * Optimise expression for challenging targets, including low-yield, toxic, insoluble, or membrane proteins. * Integrate expression workflows with downstream purification and ch
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