CRISPR Therapeutics
Biopharmaceutical
SeniorScientist,Oligonucleotide
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“Senior Scientist, Oligonucleotide at CRISPR Therapeutics. Skills: Oligonucleotide synthesis, Purification, Analytical characterization, Process development. Lead design of synthesis. Execute automated solid-phase synthesis”
Industry & Context.
Troubleshooting
What They're Looking For.
Must Have
4.5-8+ years of experience, 2 years industrial biopharmaiotech experience, 12-15 years progressive experience, Deep understanding of phosphoramidite chemistry, Protecting group strategies, Nucleotide modifications, Hands-on experience with automated oligonucleotide synthesizers, Hands-on experience with preparative purification systems, Troubleshooting mass spectrometry data, Interpreting mass spectrometry data
Nice to Have
Familiarity with ICH guidelines, Familiarity with cGMP manufacturing environments, Problem-solving skills, Ability to thrive in fast-paced environment, Ability to thrive in matrixed environment, Excellent written communication skills, Excellent verbal communication skills, Presenting data to technical stakeholders, Presenting data to non-technical stakeholders, Proven ability to lead projects, Foster a collaborative team environment
What You'll Do.
Lead design of synthesis
Execute automated solid-phase synthesis
Develop purification processes
Optimize purification processes
Oversee structural elucidation
Perform purity assessments
Drive optimization of synthetic routes
Drive optimization of cleavage methodologies
Drive optimization of deprotection methodologies
Evaluate novel chemical modifications
Implement novel chemical modifications
Evaluate conjugation strategies
Implement conjugation strategies
Evaluate delivery technologies
Implement delivery technologies
Serve as oligochemistry lead
Supervise junior chemists
Mentor junior chemists
Train junior chemists
Supervise laboratory technicians
Mentor laboratory technicians
Train laboratory technicians
Maintain laboratory notebooks
Contribute to regulatory filings
Manage inventory of oligonucleotides
Manage inventory of critical reagents
Manage inventory of phosphoramidites
Prepare experimental reports
Communicate project results
How You'll Work.
Team & Collaboration
Multidisciplinary project teams
Communication Scope
Scientific communications; Internal meetings; External meetings
Full Job Description
_**Job Description:**_ **Company Overview** Founded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY® (exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics has established strategic collaborations with leading biopharmaceutical partners, including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California. **Position Summary** We are seeking a highly skilled and motivated Senior Oligonucleotide Scientist to join our non-viral delivery (NVD) technical development team. In this role, you will serve as a technical lead in the design, synthesis, purification and analysis of modified oligonucleotides. You will drive the innovation in chemical modifications, scale-up process development and optimizations to support our advancing pipelines from early-stage research and discovery through clinical development. The ideal candidate possesses deep expertise in solid-phase synthesis, state of the art purification techniques, and analytical characterization, combined with a proven tr
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