LGC Group
Life Sciences
SeniorScientistI,ProcessDevelopment
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“Senior Scientist I, Process Development at LGC Group. Skills: Oligonucleotide synthesis, Process development, cGMP manufacturing. Lead process development of all unit operations. Perform solid phase synthesis”
Industry & Context.
Problem-solving skills; Troubleshoot challenges
What They're Looking For.
Must Have
Bachelor's degree in Chemistry, Biology, Biochemistry, or related discipline with 7+ years of applicable experience, Master's degree with 5+ years of applicable experience, Ph.D. with 0–3 years of experience in a related field, Advanced technical understanding of oligonucleotide manufacturing processes, Hands-on experience with relevant chemistry techniques, equipment, and methods, Ability to manage multiple development projects simultaneously, Maintain attention to detail and deliverable timelines
Nice to Have
Technical understanding of oligonucleotide manufacturing processes, Hands-on experience with relevant chemistry techniques, equipment, and methods, Working knowledge of ChemDraw, Working knowledge of Unicorn software
What You'll Do.
Lead process development of all unit operations
Perform solid phase synthesis
Perform cleavage and deprotection
Perform preparative HPLC purification
Perform conjugation chemistry
Perform ultrafiltration/diafiltration
Perform lyophilization
Prepare samples for Analytical Development Team
Provide technical support to manufacturing team
Serve as SME in process development of oligonucleotide
Research novel techniques
Implement novel techniques
Design complex experiments
Execute complex experiments
Interpret complex experiments
Lead technical discussions with internal teams
Lead technical discussions with clients
Define development strategies
Troubleshoot challenges
Drive project deliverables
Author technical documentation
Review technical documentation
Collaborate with cross-functional teams
Integrate development solutions into production workflows
Maintain working knowledge of regulatory guidelines
Ensure compliance across tech transfer activities
Provide mentorship to junior scientists
Provide technical guidance to junior scientists
How You'll Work.
Team & Collaboration
Cross-functional teams; Internal teams; External partners; Analytical Development; Quality Control; Manufacturing
Communication Scope
Written communication; Verbal communication; Client updates
Process & Methodology
Project plans
Full Job Description
Axolabs is a business unit of LGC, and a leading provider of CRO / CDMO capability to the therapeutic oligonucleotide discovery and development industry. Centred out of LGC’s site in Kulmbach, Germany, Axolabs works closely with its customers to assist the identification and development of lead candidates with a broad suite of bioinformatics, biology, chemistry, manufacturing and analytical services that support discovery, pre-clinical and clinical trials and scale-up manufacture. With a track record in Nucleic Acid Therapeutics that traces back more than 20 years, Axolabs provides deep knowledge and expertise in the services it provides, working collaboratively and responsively with its clients to assist them in achieving their objectives. Axolabs facility in Petaluma is focused on manufacturing scale-up and production to cGMP of multigram to kilograms of API for pre-clinical and clinical development. Our site in California has been involved in oligonucleotide synthesis for three decades and established the therapeutics activity in 2019. With around 70 staff and two manufacturing trains, Axolabs offers a flexible manufacturing service out of Petaluma that draws where necessary on our industry and chemical and analytical expertise in Kulmbach. Position Summary: The Senior Scientist in LGC Axolabs Process Development will serve as a subject matter expert (SME) in scale up/down solid-phase oligonucleotide synthesis, purification, concentration, conjugation, and downstream processing steps in preparation for handover to routine manufacturing. This role involves leading process development initiatives, providing technical guidance to cross-functional teams, and engaging with clients to ensure successful and timely execution of each assigned program. LGC Axolabs has an extensive, ever-evolving global client base along with impressive technical capabilities within a state-of-the-art GMP facility. As the needs for the organization continue to grow, we are seeking technical
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