LGC Group

Life Sciences

SeniorScientistI,ProcessDevelopment

$94–156k Petaluma, California, United States FULL TIME
Market Sentiment
HIGH DEMAND

Neural analysis suggests this role is
optimal for mid candidates.

The Brief

“Senior Scientist I, Process Development at LGC Group. Skills: Oligonucleotide synthesis, Process development, cGMP manufacturing. Lead process development of all unit operations. Perform solid phase synthesis”

Industry & Context.

Life Sciences
Problems you'll solve

Problem-solving skills; Troubleshoot challenges

What They're Looking For.

Must Have

Bachelor's degree in Chemistry, Biology, Biochemistry, or related discipline with 7+ years of applicable experience, Master's degree with 5+ years of applicable experience, Ph.D. with 0–3 years of experience in a related field, Advanced technical understanding of oligonucleotide manufacturing processes, Hands-on experience with relevant chemistry techniques, equipment, and methods, Ability to manage multiple development projects simultaneously, Maintain attention to detail and deliverable timelines

Nice to Have

Technical understanding of oligonucleotide manufacturing processes, Hands-on experience with relevant chemistry techniques, equipment, and methods, Working knowledge of ChemDraw, Working knowledge of Unicorn software

What You'll Do.

Lead process development of all unit operations

Perform solid phase synthesis

Perform cleavage and deprotection

Perform preparative HPLC purification

Perform conjugation chemistry

Perform ultrafiltration/diafiltration

Perform lyophilization

Prepare samples for Analytical Development Team

Provide technical support to manufacturing team

Serve as SME in process development of oligonucleotide

Research novel techniques

Implement novel techniques

Design complex experiments

Execute complex experiments

Interpret complex experiments

Lead technical discussions with internal teams

Lead technical discussions with clients

Define development strategies

Troubleshoot challenges

Drive project deliverables

Author technical documentation

Review technical documentation

Collaborate with cross-functional teams

Integrate development solutions into production workflows

Maintain working knowledge of regulatory guidelines

Ensure compliance across tech transfer activities

Provide mentorship to junior scientists

Provide technical guidance to junior scientists

How You'll Work.

Team & Collaboration

Cross-functional teams; Internal teams; External partners; Analytical Development; Quality Control; Manufacturing

Communication Scope

Written communication; Verbal communication; Client updates

Process & Methodology

Project plans

Full Job Description

Axolabs is a business unit of LGC, and a leading provider of CRO / CDMO capability to the therapeutic oligonucleotide discovery and development industry. Centred out of LGC’s site in Kulmbach, Germany, Axolabs works closely with its customers to assist the identification and development of lead candidates with a broad suite of bioinformatics, biology, chemistry, manufacturing and analytical services that support discovery, pre-clinical and clinical trials and scale-up manufacture. With a track record in Nucleic Acid Therapeutics that traces back more than 20 years, Axolabs provides deep knowledge and expertise in the services it provides, working collaboratively and responsively with its clients to assist them in achieving their objectives. Axolabs facility in Petaluma is focused on manufacturing scale-up and production to cGMP of multigram to kilograms of API for pre-clinical and clinical development. Our site in California has been involved in oligonucleotide synthesis for three decades and established the therapeutics activity in 2019. With around 70 staff and two manufacturing trains, Axolabs offers a flexible manufacturing service out of Petaluma that draws where necessary on our industry and chemical and analytical expertise in Kulmbach. Position Summary: The Senior Scientist in LGC Axolabs Process Development will serve as a subject matter expert (SME) in scale up/down solid-phase oligonucleotide synthesis, purification, concentration, conjugation, and downstream processing steps in preparation for handover to routine manufacturing. This role involves leading process development initiatives, providing technical guidance to cross-functional teams, and engaging with clients to ensure successful and timely execution of each assigned program. LGC Axolabs has an extensive, ever-evolving global client base along with impressive technical capabilities within a state-of-the-art GMP facility. As the needs for the organization continue to grow, we are seeking technical

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