SeniorScientist,CardiacPreservation(OrganPerfusion)

## What You'd Do Develop and execute ex vivo heart perfusion protocols, including normothermic machine perfusion (NMP), to maintain and evaluate cardiac viability before and after cryopreservation. Build out the heart viability assessment toolkit, including contractile and hemodynamic function, perfusion metrics, metabolic and lactate profiling, histology, and omics. Propose and test adjustments to cryoprotectant formulations, loading/unloading, cooling, and rewarming protocols to optimize cardiac health and recovery. Translate detailed knowledge of cardiac physiology and biology into experimental design and interpretation across the team. ## About You Deep, hands-on expertise in ex vivo heart perfusion, ideally including normothermic machine perfusion (NMP) of the heart. Intimate understanding of cardiac physiology and biology, including myocardial metabolism, contractile function, and ischemia/reperfusion injury. Experience designing and running organ viability assessments and interpreting multimodal readouts (functional, metabolic, histological, omics). Comfort working at the bench in an ex vivo model and a track record of executing complex experimental protocols. Demonstrated success working through hard, open-ended problems, with a passion for rapid problem solving and rapid exploration of unfamiliar topics and protocols. Ability to think from first principles and tackle complex, cross-disciplinary problems alongside other scientists and engineers. ## Preferred Qualifications PhD in a STEM field, ideally in cardiac physiology, organ preservation, or transplant — or significant (4+ years) experience as a scientific leader in an industry context. Direct experience with cardiac transplant or heart preservation research.