Regeneron
Healthcare
SeniorScientist:BispecificsandAntibodyEngineering
Neural analysis suggests this role is
optimal for Senior candidates.
“Senior Scientist: Bispecifics and Antibody Engineering at Regeneron. Skills: Antibody engineering, Bispecific antibodies, Protein therapeutics. Design antibody therapeutics. Design protein therapeutics”
What You'll Achieve.
Contribute to pipeline; Build new platform capabilities
Industry & Context.
Troubleshoot assays; Troubleshoot production
What They're Looking For.
Must Have
PhD in molecular biology, PhD in cell biology, PhD in biochemistry, PhD in immunology, 1 year relevant experience, Cloning experience, Antibody expression experience, Mammalian cell lines experience, Antibody purification experience, Protein characterization experience
Nice to Have
Cell-free expression familiarity, Structural AI/ML-design familiarity
What You'll Do.
Design antibody therapeutics
Design protein therapeutics
Produce antibody therapeutics
Produce protein therapeutics
Characterize antibody therapeutics
Characterize protein therapeutics
Apply molecular biology expertise
Apply structural biology expertise
Design multi-specific antibodies
Perform guided design
Characterize binding affinities
Characterize binding kinetics
Characterize stability
Design biochemical assays
Implement biochemical assays
Design cell-based assays
Implement cell-based assays
Troubleshoot assay data
Communicate biologic designs
Convey results to management
Maintain accurate entries
How You'll Work.
Team & Collaboration
Program stakeholders; Cross-departmental meetings; Diverse teams
Communication Scope
Communicate designs; Convey results
Full Job Description
We are seeking a results-driven Senior Scientist to join Regeneron’s Antibody Engineering team within the Bispecifics and Antibody Engineering Department. In this fast-paced, innovative group, you will design, produce, and characterize next-generation antibody and protein therapeutics across multiple therapeutic areas with a focus on myeloid cell biology. Your work will directly contribute to the pipeline and help build new platform capabilities at a pivotal time for antibody engineering. **** **As a Senior Scientist, a typical day could require the following:** * Apply molecular and structural biology expertise to independently design innovative multi-specific antibodies with desired potency, selectivity and developability. * Perform molecular and structural-guided design, high-throughput construct generation, and vector engineering using modern software and tools. * Produce and purify novel and logic-gated alternative format antibodies using mammalian expression systems utilizing an assortment of molecular biology & biochemical techniques (i.e. AKTA systems and other chromatographic columns). * Characterize binding affinities, binding kinetics & stability. * Design and implement high-throughput and properly controlled biochemical and cell-based assays (ELISA and AlphaLISA, flow cytometry binding, phagocytic assays, cell activation and cytolytic assays). * Troubleshoot bioanalytical and cell-based assay data to inform subsequent iterations. * Engage program stakeholders to communicate biologic designs with data updates to meet program objectives. * Clearly convey results to management during cross-departmental meetings and maintain timely, accurate entries using Benchling and research ELN. **This role may be a strong fit If You:** * Have expertise in myeloid, molecular, and protein biology. * Learn new skills quickly and troubleshoot antibody production and functional assays effectively. * Excel in data analysis and interpretation while supporting multiple projects
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