Crinetics
pharmaceutical
SeniorScientist1,InVitroPharmacology
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“Senior Scientist 1, In Vitro Pharmacology at Crinetics. Skills: GPCR pharmacology, in vitro pharmacology assays, drug discovery, assay development. Engineer and execute in vitro mechanism of action (MoA) and translational studies. Pioneer new technology and assay development initiatives”
What You'll Achieve.
Advance the in vitro pharmacology department’s capabilities.; Generate high quality, reproducible data.; Ensure all work meets quality standards.
Industry & Context.
Outstanding experimental design and problem-solving skills; Rigorous approach to complex data analysis.
Biology and chemical laboratory environment experience needed., Environmental health and safety requirements also apply., Travel: You may be required to travel for up to 5% of your time., Physical Activities: On a continuous basis, sit at desk for a long period of intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 25 lbs. may be required.
What They're Looking For.
Must Have
Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with a minimum of 3-5 years of relevant experience., BS or MS degrees must demonstrate a minimum of 11 years of relevant experience., GPCR Specialization: Demonstrated expertise of small molecule GPCR pharmacology, including theoretical understanding of signaling models, mechanisms, and experimental design., Assay Proficiency: Proven technical expertise in developing and executing biochemical, cellular, and radioligand binding assay systems with a focus on high-quality data generation., Scientific Innovation: Ability to leverage existing literature to develop methods, protocols, and technologies that advance pharmacological capabilities., Analytical Excellence: Outstanding experimental design and problem-solving skills, with a rigorous approach to complex data analysis., Adaptability: Proven ability to thrive in a fast-paced, dynamic environment and pivot effectively as program priorities evolve., Communication: Exceptional written and verbal communication skills, with a proven ability to collaborate effectively across multidisciplinary teams., A work ethic characterized by detail-orientation, reliability, and an enthusiasm for both high-level laboratory work and complex data analysis.
What You'll Do.
Engineer and execute in vitro mechanism of action (MoA) and translational studies
Pioneer new technology and assay development initiatives
and execute in vitro pharmacology assays
Evaluate and establish novel in vitro technologies
Perform translational experiments
Engineer and maintain multiple mammalian cell lines
Generate high quality
Meticulous documentation of protocols and results
Critically analyze and interpret complex data
Explore and establish PK/PD relationships
Uphold scientific integrity
Perform rigorous data scrutiny
Ensure total compliance with institutional safety standards
data management policies
and laboratory practices
How You'll Work.
Team & Collaboration
Collaborate effectively across multidisciplinary teams; Synthesize and effectively communicate findings to multidisciplinary teams through informal updates, formal presentations, and reports.; Mentor junior staff through hands-on technical instruction, creation of standardized SOPs, and data oversight.
Communication Scope
Exceptional written and verbal communication skills; Effectively communicate findings to multidisciplinary teams through informal updates, formal presentations, and reports.
Full Job Description
Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We were founded by a dedicated team of scientists with the simple belief that better therapies developed from rigorous innovation can lead to better lives. Our work continues to make a real difference in the lives of patients. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. **Position Summary:** We are seeking a highly motivated and collaborative Senior Scientist 1 with experience in GPCR pharmacology and drug discovery to join our growing and dynamic in vitro pharmacology team. The successful candidate will engineer and execute in vitro mechanism of action (MoA) and translational studies, while pioneering new technology and assay development initiatives to advance the in vitro pharmacology department’s capabilities. **Essential Job Functions and Responsibilities:** These may include but are not limited to: Assay Development & Lab Execution * Design, develop, and execute in vitro pharmacology assays (e.g., biochemical, cell-based functional, and radioligand binding) to characterize GPCR mechanism and signaling. * Evaluate and establish novel in vitro technologies to advance drug discovery. * Perform translational experiments that bridge in vitro activity with predicted human outcomes * Engineer and maintain multiple mammalian cell lines in culture to support ongoing assay needs. * Generate high quality, reproducible data, and ensure meticulous documentation of protocols and results
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