SeniorManager,CGTOperationsBusinessProcess

**Job Description** **About Vertex:** At Vertex, we are relentless in our pursuit of transformative medicines to improve the lives of people with serious diseases. Our Global Heme Cell and Gene Therapy (CGT) Operations team is at the forefront of innovation, commercial strategy, and operational excellence, driving the evolution of the global, cross-functional, "vein to vein” business process for CASGEVY, the only CRISPR-based autologous gene therapy approved for people living with Sickle Cell Disease and Transfusion dependent beta thalassemia. **Position Summary:** We are seeking a **Senior Manager, CGT Operations Business Process** to lead global business process initiatives for CASGEVY. This critical role will collaborate cross-functionally to design and own the end-to-end process, essential to delivering a vein-to-vein, autologous product. As CASGEVY continues to scale across 9+ markets globally, the successful candidate will drive process optimization and operational excellence cross-functionally in a GxP-regulated environment. **Key Responsibilities:** * Lead the evolution of the Global end-to-end (E2E) process by identifying and addressing improvement areas and process gaps in collaboration with stakeholders across commercial, quality, systems, and manufacturing, spearheading workstreams to design and implement changes to increase efficiency and drive strategic priorities * Own and evolve global documentation leveraged by stakeholders across all markets and functions to ensure alignment, including business process maps, standard operating procedures, and other GxP materials * Manage cross-functional forums to advance business process initiatives, gather insights, and problem-solve operational challenges, driving scalability through simplification, clarity, and standardization of process * Lead the global commercial GxP change management process, holistically assessing impact of updates to a complex business process in collaboration with subject matter experts