SeniorMachineLearningScientist

POSITION SUMMARY: Natera is seeking a Senior Machine Learning Scientist to join our AI team, an advanced R&D and core AI innovation team bridging the gap between molecular discovery and clinical execution. Leveraging a proprietary data moat of over 250,000 oncology patients profiled with longitudinal ctDNA, WES/WGS, digital pathology, and EMR data, you will design and deploy production-grade autonomous AI agents and multi-modal foundation models. Your mission is to architect systems capable of multi-step biological reasoning, converting complex multi-omic datasets into verifiable clinical insights that accelerate biomarker and therapeutic discovery. You will lead the next evolution of our Agentic AI platform, designing autonomous systems capable of reasoning through the complexities of cancer biology, orchestrating proprietary foundation models, and simulating virtual patient trajectories. PRIMARY RESPONSIBILITIES Lead the technical design and deployment of multi-agent systems capable of autonomous hypothesis generation and tool use, including genomic variant calling, LLM fine-tuning, and clinical trial matching pipelines Incorporate and advance Natera’s transformer-based foundation model by integrating DNA, RNA, and H&E imaging modalities for multi-step biological reasoning and tool use Implement advanced LLM reasoning frameworks, such as ReAct and Chain-of-Thought, alongside reinforcement fine-tuning (RFT) to ensure agents provide accurate, explainable clinical rationales Architect systems that autonomously translate complex, multi-modal data into diagnostic and therapeutic insights with human-verifiable reasoning and tracing Own the technical strategy and product roadmap for agentic workflows across the Biopharma Solutions and Therapeutics Discovery division, converting complex clinical challenges into scalable AI systems Establish production-grade machine learning engineering standards and reproducible architectures across the AI team to ensure absolute model tr