CRISPR Therapeutics
Biopharmaceutical
SeniorEngineerII,mRNAProcessDevelopment
Neural analysis suggests this role is
optimal for Senior candidates.
“Senior Engineer II, mRNA Process Development at CRISPR Therapeutics. Skills: mRNA Process Development, Nucleic Acid Chemistry, Purification Techniques, Process Scale-up. Lead development of upstream unit operations. Lead optimization of upstream unit operations”
Industry & Context.
Troubleshooting
What They're Looking For.
Must Have
Ph.D. in Chemical Engineering, Bioengineering, Biochemistry, or related discipline, 2-4.5+ years industry experience, 10-12 years relevant experience (Non PhD), Core mRNA Expertise, Hands-on, deep expertise in IVT kinetics, Hands-on, deep expertise in plasmid DNA linearization, Extensive experience with Tangential Flow Filtration, Extensive experience with various chromatography modes, Experience operating automated chromatography systems, Experience operating filtration skids, Proficiency with statistical software for DoE, Proficiency with statistical software for data analysis
Nice to Have
Experience with mRNA-LNP formulation, Familiarity with GMP regulations, Familiarity with Quality by Design principles, Familiarity with preparing regulatory filing documentation, Prior experience managing junior researchers, Prior experience directly mentoring junior researchers
What You'll Do.
Lead development of upstream unit operations
Lead optimization of upstream unit operations
Lead scale-up of upstream unit operations
Lead development of downstream unit operations
Lead optimization of downstream unit operations
Lead scale-up of downstream unit operations
Apply Design of Experiments
Apply statistical analysis
Evaluate process parameters
Ensure consistent product quality
Drive tech transfer to internal teams
Drive tech transfer to external CDMOs
Author technical reports
Author Standard Operating Procedures
Author tech transfer documentation
Provide on-the-floor technical support
Provide troubleshooting during scale-up
Provide troubleshooting during GMP manufacturing
Partner with analytical development
Correlate process changes with quality attributes
Mentor research associates
Guide research associates
Represent technical development function
Present data to senior leadership
How You'll Work.
Team & Collaboration
Cross-functional project teams; Research innovation; Analytical development; Manufacturing operations
Communication Scope
Technical reporting; Present data
Process & Methodology
Technical strategy
Full Job Description
_**Job Description:**_ **Company Overview** Founded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY® (exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics has established strategic collaborations with leading biopharmaceutical partners, including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California. **Position Summary** We are seeking a highly motivated and innovative Senior Engineer II to join our Non-viral delivery technical development team. In this role, you will lead the design, optimization, and scale-up of robust manufacturing processes for our gene editing mRNA therapeutics. You will bridge the gap between research innovation and clinical development, utilizing your deep technical expertise in nucleic acid chemistry, enzymatic reactions, and purification methodologies. As a senior member of the team, you will drive technical strategy, mentor junior staff, and collaborate closely with research innovation, analytical development, and manufacturing operation
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