Esobiotec

biotechnological research

Scientist/SrScientistR&DManufacturing

Mont-Saint-Guibert, Belgium FULL TIME
The Brief

“Scientist/Sr Scientist – R&D Manufacturing at Esobiotec. Skills: lentiviral vector, process development, downstream purification, viral vector engineering. Plan downstream purification. Execute R&D grade vectors”

What You'll Achieve.

achieve target purity; potency; stability

Industry & Context.

biotechnological research
Problems you'll solve

hypothesis-driven process development experiments

What They're Looking For.

Must Have

MS or PhD in bioengineering, biotechnology, cell/molecular biology, or related field with relevant industry experience in process development for viral vectors, >5+ years of industry experience in manufacturing and/or process development, with demonstrated contributions to LVV or other viral vector manufacturing, scientific/technical writing skills (e. g. development reports and tech transfer documents) and communication skills (e. g. data presentation) in English is required, Organized, proactive, and product-focused with commitment to safety, data integrity, and continuous improvement while operating under timeline and resource constraints, inter-personal and communication skills, Proven record of collaborations and effective work with internal and external partners

Nice to Have

Practical expertise in downstream processing for LVV (preferred), such as clarification, chromatography, TFF, and formulation to achieve target purity, potency, and stability, Proficiency with bioreactors (such Scale X, iCellis, DASbox® or SciVario® Bioreactor System), Competence in analytical techniques relevant to LVV including qPCR/ddPCR, ELISA, flow cytometry, infectivity assays, and impurity profiling in partnership with analytics teams, Exposure to technology transfer and GMP manufacturing environments with understanding of documentation, change control, and compliance expectations, Cross-functional collaboration skills with discovery teams, and clear communication to technical and non-technical audiences

What You'll Do.

Plan downstream purification

Execute R&D grade vectors

Test manufacturability

Develop downstream processes

Optimize manufacturing processes

Execute process development experiments

Support cell line development

Prepare technical documentation

Collaborate with stakeholders

Maintain documentation

How You'll Work.

Team & Collaboration

Collaborate with discovery, vector engineering, and CMC stakeholders; Contribute to decision-making forums; Collaborate with global process development team; Cross-functional collaboration skills with discovery teams

Communication Scope

clear communication to technical and non-technical audiences; data presentation

Process & Methodology

maintaining clear timelines, milestone accountability

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