Lilly
Biotechnology
Scientist/Sr.Scientist-ProteinEngineering
Neural analysis suggests this role is
optimal for Mid candidates.
“Scientist/Sr. Scientist - Protein Engineering at Lilly. Skills: Protein Engineering, Antibody Engineering, Phage Display, Molecular Biology, Biochemistry, Biophysical Assays. Engineer, characterize, and optimize antibodies, multispecifics, therapeutic proteins, and alternative scaffolds using rational design and library-based approaches. Execute phage display campaigns including library construction, biopanning, clone screening, and hit identification”
What You'll Achieve.
achieve critical research objectives and timelines
Industry & Context.
Excellent analytical skills
Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.
What They're Looking For.
Must Have
Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Protein Engineering, Biotechnology, Cell Biology, or a related field, minimum of 3+ years of relevant laboratory experience, authorized to work in the United States on a full-time basis
Nice to Have
Demonstrated hands-on experience with molecular biology and cloning techniques (PCR, Gibson assembly, restriction digest/ligation, site-directed mutagenesis, bacterial transformation), Experience with phage display experience with antibody (scFv, Fab) or single-domain antibody libraries is preferred, Experience with protein or antibody engineering and optimization approaches, Proficient in ELISA and binding assay experience with BLI (Octet) or SPR (Biacore) is desirable, Knowledge of protein structure and structure-activity relationships, Knowledge/experience in cell culture and cell-based functional assays, Experience working with automation platforms, Computational skills such as Python or R for data analysis, scripting, or bioinformatics workflows, Familiarity with next-generation sequencing (NGS) data in the context of antibody discovery or directed evolution
What You'll Do.
and optimize antibodies
and alternative scaffolds using rational design and library-based approaches
Execute phage display campaigns including library construction
and hit identification
Perform molecular cloning (PCR
site-directed mutagenesis
restriction digest/ligation) to support construct generation and library construction
and execute biochemical and biophysical assays (ELISA
SDS-PAGE) to characterize engineered variants
Analyze sequencing data to confirm construct identity and triage candidates for downstream evaluation
Contribute to process improvement of molecular biology
and screening protocols
How You'll Work.
Team & Collaboration
Work collaboratively and communicate with project teams to achieve critical research objectives and timelines; work collaboratively with the antibody discovery, protein engineering, protein production, protein characterization, and automation groups
Communication Scope
communicate with project teams; written communication skills; oral communication skills
Full Job Description
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Company Overview: At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. The Biotechnology Discovery Research (BioTDR) division in San Diego is responsible for generating, characterizing, and optimizing biotherapeutics from discovery to candidate selection. We support cross-disciplinary efforts to engineer innovative biotherapeutics that treat metabolic, autoimmune, oncologic, and neurologic diseases. Join our team of scientists working to improve the lives of patients around the world. This is an opportunity to join the Protein Engineering group at the Lilly Biotechnology Center in San Diego. We are seeking an associate-level scientist with experience in molecular biology, biochemistry, and protein engineering. The successful candidate will engineer, characterize, and optimize antibodies, therapeutic proteins, and alternative scaffolds—with a primary focus on antibody optimization and a supporting role in phage display–based discovery. The ideal candidate is a dedicated teammate with outstanding technical skills who can work collaboratively with the antibody discovery, protein engineering, pr
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