Glyphic Biotechnologies
Biotechnologies
Scientist/SeniorScientist,AssayDevelopment(SamplePrep)
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“Scientist / Senior Scientist, Assay Development (Sample Prep) at Glyphic Biotechnologies. Skills: Assay Development, Sample Preparation, Proteomics, Protein sequencing. Design, test, and optimize inputs for ProSE experiments. Lead integration of novel chemistry developments”
Industry & Context.
Independently troubleshoots complex technical challenges; Excellent problem-solving skills; Navigates complex team dynamics, partnerships, and challenges with creativity and logic; Treats obstacles as problems to be creatively solved, not reasons something can’t be done; Applies sound judgment to the best available information, testing, learning, and iterating
What They're Looking For.
Must Have
PhD / MS / BS with 4+ / 6+ / 8+ years of relevant experience (Senior Scientist), PhD / MS / BS with 0+ / 2+ / 4+ years of relevant experience (Scientist I), Demonstrated expertise in developing and optimizing ultrasensitive proteomic assays from real biological samples, Experience generating quantitative readouts across diverse analytical platforms, Experience processing real biological samples from various sources, Expertise with developing sample preparation or enrichment methods for low-abundance targets or limited input material, Understanding of peptide chemistry, Strategies to prevent degradation of post-translational modifications, Excellent problem-solving skills, Attention to detail, Excellent written and verbal communication skills, Ability to collaborate effectively across diverse scientific and technical backgrounds, Ability to thrive in a fast-paced environment with evolving priorities
Nice to Have
Deep familiarity with highly multiplexed, high-sensitivity protein quantification platforms, Experience with nanopore platforms for sequencing or label-free detection, Experience with single-cell or spatial proteomics and transcriptomics, Comfort working with R or Python to input experimental results and navigate established data analysis workflows
What You'll Do.
and optimize inputs for ProSE experiments
Lead integration of novel chemistry developments
Optimize and integrate C-terminal and side-chain blocking chemistries
Propose and qualify in-process controls
Apply chemoenzymatic synthesis approaches
Characterize individual enzymatic reaction steps
Introduce and validate real biological sample inputs
Evaluate and process incoming Key Opinion Leader (KOL) samples
Assess diverse sample types
Develop extraction and purification protocols
Develop and implement strategies for sample enrichment
Support generation and sourcing of standard reference materials
Establish instrumentation for production and purification
How You'll Work.
Team & Collaboration
Collaborate effectively across diverse scientific and technical backgrounds; Collaborating with chemists; Navigates complex team dynamics, partnerships, and challenges; Work with product team
Communication Scope
Excellent written and verbal communication skills; Communicates effectively across multidisciplinary teams
Full Job Description
About Glyphic: At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing. What we are looking for in you We are seeking a technically driven, detail-oriented, and collaborative Scientist to support sample preparation method development. Reporting to the Director of Assay Development you will test and optimize Glyphic’s single-molecule protein sequencing platform, ensuring it achieves industry-leading metrics for robustness, sensitivity, and scalability. A critical component of this work involves developing and integrating specialized sample preparation protocols for diverse biological inputs with stringent downstream requirements for high-purity and high-accuracy proteomic applications. Your work will directly advance the development of a high-throughput, end-to-end sequencing solution built for real-world samples. The ideal candidate independently troubleshoots complex technical challenges, rapidly iterates on experimental designs, and communicates effectively across multidisciplinary teams. A track record of adapting protocols for novel sample types and executing within high-throughput environments will be key to making an immediate impact. This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location. What you’ll do Assay Development Design, test, and optimize inputs for ProSE experiments for robustness, sensitivity, and scalability, including improving reaction efficiency and accuracy. Lead the integration of novel chemistry developments into sample preparation and assay workflows, driving high-precision proteomic peptide generat
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