Scientist,ProcessDevelopment(Formulation)

**The Role** Moderna is seeking a highly skilled and motivated Individual to develop stable, fit-for-purpose enzyme formulations for DNA template manufacturing in support of Moderna’s mRNA medicines portfolio. This lab-based role will design and execute formulation, stability, compatibility, and use-condition studies for enzymes used in DNA manufacturing workflows. The work will translate enzyme performance needs into practical formulation compositions, storage conditions, and handling instructions that preserve activity, consistency, and process performance. The Candidate will work most closely with enzyme process development and analytical development to define formulation requirements, measure enzyme performance, and troubleshoot stability or activity losses. As formulations mature, this individual will provide technical inputs to tech transfer formulation process into manufacturing with clear material attributes, handling controls, and documentation. **Here’s What You’ll Do** * Design and execute enzyme formulation studies to identify buffer, pH, ionic strength, stabilizer, surfactant, cryoprotectant, concentration, and storage conditions for enzymes used in DNA template manufacturing. * Develop stability study designs that evaluate enzyme activity, purity, degradation, aggregation, adsorption, concentration recovery, and functional performance under process-relevant conditions. * Assess formulation robustness during freeze/thaw, hold time, dilution, mixing, temperature exposure, agitation, contact-material exposure, and other handling conditions relevant to development and manufacturing use. * Use enzyme activity assays, biochemical/biophysical characterization, and DNA process performance readouts to connect formulation attributes to manufacturing outcomes. * Identify degradation or performance-loss mechanisms and propose formulation or handling changes based on scientific rationale and experimental data. * Apply DOE, risk-based study design, and fit-for-purpo