Amgen
Biotech
Scientist–InVitroHighContentImagingAssayDevelopmentandExecutionSupportingsiRNAPrograms
“Scientist – In Vitro High-Content Imaging Assay Development and Execution Supporting siRNA Programs at Amgen. Skills: In Vitro High-Content Imaging Assay Development, siRNA, high-content imaging, RNA FISH, qRT-PCR, HTS, automation. Design, develop, and validate quantitative cell-based transcriptional assays (high-content RNA FISH, qRT-PCR) suitable for HTS/automation.. Implement assay miniaturization and automation workflows with HTS collaborate with automation engineers to deliver reproducible,”
What You'll Achieve.
translate screening data into prioritized siRNA candidates and downstream characterization plans; identify potential therapeutic candidates; deliver reproducible, high throughput runs; deliver high quality data; drive decisions for candidate progression
Industry & Context.
critical thinking; troubleshooting skills
What They're Looking For.
Must Have
Doctorate degree OR Master’s degree and 2 years of In Vitro High-Content Imaging Assay Development experience OR Bachelor’s degree and 4 years of In Vitro High-Content Imaging Assay Development experience
Nice to Have
Excellent cell culture techniques, Experience with siRNA transfection and RNA FISH assays, High-content imaging assay development using Opera Phenix, Familiarity with lab automation instruments, critical thinking and troubleshooting skills
What You'll Do.
and validate quantitative cell-based transcriptional assays (high-content RNA FISH
qRT-PCR) suitable for HTS/automation.
Implement assay miniaturization and automation workflows with HTS collaborate with automation engineers to deliver reproducible
high throughput runs.
Independently lead multiple screening projects and deliver high quality data
and coordinate follow-up validation experiments.
Proactively participate in siRNA program meetings
communicate results and technical recommendations to Genetic Medicine and therapeutic-area partners
drive decisions for candidate progression.
Contribute to siRNA delivery
uptake and cellular localization by utilizing high-content Imaging assays and automation platforms.
How You'll Work.
Team & Collaboration
partner closely with the Genetic Medicine team and cross-functional collaborators, including teams in molecular biology, bioinformatics, therapeutic areas, and automation/engineering; Proactively participate in siRNA program meetings, communicate results and technical recommendations to Genetic Medicine and therapeutic-area partners
Communication Scope
communicate results and technical recommendations
Process & Methodology
Independently lead multiple screening projects
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