CRISPR Therapeutics
Biotech
ScientistII,LNP
Neural analysis suggests this role is
optimal for Mid candidates.
“Scientist II, LNP at CRISPR Therapeutics. Skills: Nucleic acid encapsulation, Bioconjugation chemistry. Design, formulate, and optimize novel LNP compositions. Perform comprehensive analytical characterization of nanoparticles”
Industry & Context.
Troubleshoot technical challenges; Problem-solving skills
What They're Looking For.
Must Have
PhD with 2-5 years relevant experience or postdoctoral experience, Non-PhD with 10-12+ years relevant experience, Deep, hands-on experience in formulation of lipid nanoparticles, Demonstrated experience encapsulating nucleic acids, Experience with bioconjugation chemistry, Experience with protein modification and purification, Proficiency in nanoparticle characterization techniques, Problem-solving skills, Ability to design experiments independently, Excellent communication skills, Highly collaborative, team-oriented mindset
Nice to Have
Knowledge of LNP process development, Knowledge of scale-up, Knowledge of stability testing, Experience with HPLC/UPLC for lipid and payload analysis, Familiar with in vivo models, Experience working in fast-paced biotech industry, Experience working in pharmaceutical industry, Understanding of Design of Experiments (DoE) principles
What You'll Do.
and optimize novel LNP compositions
Perform comprehensive analytical characterization of nanoparticles
Develop and execute bioconjugation strategies
Functionalize LNP surfaces with targeting ligands
and present experimental data
Design and execute experiments
Evaluate formulation performance
Evaluate formulation toxicity
Evaluate formulation efficacy
Stay current with scientific literature
Troubleshoot technical challenges
Evaluate new technologies
Maintain electronic laboratory notebooks (ELN)
Contribute to technical reports
Contribute to regulatory filings
Support patent applications
Support patent prosecutions
How You'll Work.
Team & Collaboration
Cross-functional teams; IP counsels
Communication Scope
Present experimental data; Technical reports
Full Job Description
_**Job Description:**_ **Company Overview** Founded over a decade ago, CRISPR Therapeutics is a leading biopharmaceutical company focused on developing transformative gene-based medicines for serious human diseases. The Company has evolved from a pioneering research-stage organization into an industry leader, marking a historic milestone with the approval of CASGEVY® (exagamglogene autotemcel [exa-cel]), the world’s first CRISPR-based therapy, approved for eligible patients with sickle cell disease and transfusion-dependent beta thalassemia. CRISPR Therapeutics is advancing a broad and diversified pipeline across hemoglobinopathies, cardiovascular, autoimmune, oncology, regenerative medicine and rare diseases. The Company continues to expand its leadership in gene editing through the development of SyNTase™ editing, a novel and proprietary gene-editing platform designed to enable precise, efficient, and scalable gene correction. To accelerate and expand its impact, CRISPR Therapeutics has established strategic collaborations with leading biopharmaceutical partners, including Vertex Pharmaceuticals. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Boston, Massachusetts and San Francisco, California. **Position Summary** We are seeking a highly motivated Scientist II to join our LNP team. This is a critical, hands-on laboratory role focused on the design, development, and characterization of novel nanoparticle delivery systems. The ideal candidate will have experience in lipid nanoparticle (LNP) design, formulation and characterization, with proven experience in designing novel solutions for encapsulation of different nucleic acid payloads (such as mRNA, siRNA, etc.). Experience in the space of target delivery or extra-hepatic delivery strategies is highly desirable. You will be part of a team responsible for driving the development of our delivery platform, from
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