ResearchScientist

**Job Description** At Vertex Pharmaceuticals, we are relentless in our pursuit of transforming the lives of people with serious diseases. We are seeking a highly motivated and enthusiastic **Research Scientist** to join our **Structural Biology and Biophysics team** in Boston. This is an exciting opportunity to be part of a collaborative team dedicated to producing and characterizing high-quality recombinant proteins for structural, biochemical, and biophysical studies. Your contributions will play a critical role in elucidating target mechanisms of action and ligand engagement, driving our mission to deliver transformative therapies to patients. As a Research Scientist, you will work in a dynamic, fast-paced environment, contributing to multiple projects simultaneously. You will leverage your expertise in recombinant protein expression and characterization to support drug discovery efforts. The ideal candidate is a self-motivated, detail-oriented individual who thrives in a collaborative and innovative setting. ## **Key Responsibilities:** * Express both soluble and integral membrane proteins using various recombinant systems, including bacterial, insect, and mammalian platforms. * Perform transformation, transfection, or transduction of appropriate expression systems. * Maintain and manage mammalian and insect cell lines to support protein expression. * Optimize protein expression processes to enhance yield and quality of downstream proteins. * Design, execute, and analyze experiments while managing multiple projects and priorities. * Qualify and characterize expressed proteins using analytical techniques such as SDS-PAGE, Western blot, and fluorescence-detection size-exclusion chromatography (FSEC). * Maintain detailed and accurate experimental records in an electronic lab notebook (ELN). * Effectively communicate experimental results and manage production timelines to meet project goals. **Minimum Qualifications:** **Education** : * Master’s degree (MSc) in Bio