AskBio Inc.
gene therapy
ResearchAssociateII,Bioanalytical
Neural analysis suggests this role is
optimal for Mid+ candidates.
“Research Associate II, Bioanalytical at AskBio Inc.. Skills: development, qualification, validation, and execution of assays investigating biodistribution, viral shedding, and functional assessments, extraction and quantification of nucleic material (DNA, RNA) and protein, quantify transgene expression, protein assessment. Isolate and quantify nucleic acids and proteins from various model systems and tissue types. Participate in assay design, including assay qualification and validation”
What You'll Achieve.
Pioneering science to create transformative molecular medicines.; Lead innovative science and drive clinical outcomes to transform people's lives.; Bring transformative therapeutics to patients in need.; advance science and clinical outcomes for our patients, families, and caregivers.
Industry & Context.
capable of troubleshooting independently
on-site lab-based position
What They're Looking For.
Must Have
Master’s degree in biology, chemistry, or related field OR bachelor’s degree in biology, chemistry, or related field with 2+ years’ relevant work experience OR High School Diploma and 6+ years’ relevant work experience, Hands-on experience with the processing and isolation of nucleic acids and protein from material acquired from different species and organ types, Demonstrated understanding of assay qualification and/or validation requirements, Knowledge of, and experience with, multiple assays including: ddPCR, RT-ddPCR, ELISA, western blots, and/or MSD-based platforms, Excellent technical lab skills with attention to detail and the ability to assume independent ownership of workflows, Knowledge of GxP regulatory requirements, Ability to multitask among multiple projects and teams, and work in a fast-paced, highly interactive environment, Self-motivated, organized, and capable of troubleshooting independently, Proficiency in Microsoft Office Suite (Word, Excel, PowerPoint), Excellent communication skills with ability to collaborate with colleagues across multiple communication platforms including e-mail, Microsoft Teams, and Sharepoint sites
Nice to Have
Hands-on experience with assay qualification and validation, Prior work in a regulated lab environment, Familiarity with software such as Softmax Pro, GraphPad prism, and Smartsheet, Prior use of LIMS sample management software and/or lab automation, Relevant knowledge and industrial experience with gene therapy, including AAV and/or lentiviral-based platforms
What You'll Do.
Isolate and quantify nucleic acids and proteins from various model systems and tissue types
Participate in assay design
including assay qualification and validation
Utilize molecular techniques including
but not limited to gene expression analysis
primer probe set design/validation
and MSD for sample analysis
Responsible for co-authoring and reviewing test methods
and qualification/validation reports
Contribute to data review and quality control of data in support of regulatory filings
Perform routine instrument maintenance and performance verification
Maintain organized electronic and/or paper-based documentation that is fit-for-purpose with regards to regulatory requirements.
and manage samples using LIMS
Perform data analysis and effectively communicate results in formal reports and presentations for technical discussions
Maintain inventories and/or place orders of reagents and materials needed for the assigned projects allowing for timely execution of related lab work
Ensure lab areas are clean and organized
and raw materials are available for use
How You'll Work.
Team & Collaboration
collaborate with colleagues across multiple communication platforms including e-mail, Microsoft Teams, and Sharepoint sites; Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view.
Communication Scope
Excellent communication skills with ability to collaborate with colleagues across multiple communication platforms including e-mail, Microsoft Teams, and Sharepoint sites; effectively communicate results in formal reports and presentations for technical discussions; openly communicate
Process & Methodology
Ability to multitask among multiple projects and teams
Full Job Description
AskBio Inc., a wholly owned and independently operated subsidiary of Bayer AG, is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular, central nervous system, cardiovascular, and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure, limb-girdle muscular dystrophy, multiple system atrophy, Parkinson’s disease, and Pompe disease. AskBio’s gene therapy platform includes Pro10™, an industry-leading proprietary cell line manufacturing process, and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park, North Carolina, and European headquarters in Edinburgh, Scotland, the company has generated hundreds of proprietary capsids and promoters, several of which have entered pre-clinical and clinical testing. **Our vision:** Pioneering science to create transformative molecular medicines. **Our mission:** Lead innovative science and drive clinical outcomes to transform people's lives. **Our principles:** * Advance innovative science by pushing boundaries. * Bring transformative therapeutics to patients in need. * Provide an environment for employees to reach their fullest potential. **Our values:** * Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. * Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. * Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. * Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. * Act with Uncompromising Integrity. Be honest,
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