Vertex Pharmaceuticals
Biotechnology
ProcessDevEngineeringSeniorScientist,MediaDevelopment
Neural analysis suggests this role is
optimal for Senior candidates.
“Process Dev Engineering Senior Scientist, Media Development at Vertex Pharmaceuticals. Skills: Media development, Cell culture process, Stem cell culture. Develop cell culture media. Define technical roadmaps”
What You'll Achieve.
Advance media optimizations; Enable process scaling; Cost of goods reduction; Process robustness improvement
Industry & Context.
Troubleshoot; Process understanding
Weekend work rotation
What They're Looking For.
Must Have
PhD with 2-5 years industry experience, MS with 6-9 years industry experience, BS with 8-11 years industry experience, Working knowledge of cGMP
Nice to Have
Stem cell culture experience, High throughput automated cell culture platforms experience
What You'll Do.
Develop cell culture media
Define technical roadmaps
Implement technical roadmaps
Troubleshoot raw material challenges
Develop media screening toolboxes
Optimize media screening toolboxes
Stay up to date with analytical tools
Stay up to date with omics technologies
Generate technical reports
Review technical reports
Support media preparation transfer
Support GMP manufacturing transfer
Conduct hands-on experiments
Foster innovation culture
Foster continuous improvement
How You'll Work.
Team & Collaboration
Cross functional teams; Diverse team dynamics; Internal stakeholders; External stakeholders
Communication Scope
Verbal communication; Written communication; Technical reports; Regulatory filings; External publications
Process & Methodology
Roadmaps
Full Job Description
**Job Description** **General Summary:** Cell, gene and biologic therapies are rapidly growing parts of Vertex Pharmaceuticals, where research, development, and clinical manufacturing are highly integrated together at our new R&D site in Boston Seaport. Vertex is seeking a talented individual to join our Process Development team to support media development and optimization efforts. The focus of this position is to support advancement of the innovative stem cell culture medium development and optimization for cell and gene therapy applications. This position will collaborate with cross functional teams to advance media optimizations to enable process scaling, cost of goods reduction, and process robustness improvement through fundamental process understanding. The ideal candidate has deep expertise in media development and optimization, fundamental cell culture process understanding, thrive in a fast-paced environment and proven ability to perform under pressure. The position will be based in Boston, MA. **Key Duties and Responsibilities:** * Develop robust and cost-effective cell culture media for commercial scale manufacturing. * Define and implement technical roadmaps for media development and optimization, ensuring alignment with business priorities and leadership strategy. * Troubleshoot complex raw material sourcing and control challenges, with a strong understanding of GMP, regulatory, and quality requirements. * Develop and optimize high-throughput, small-scale media screening toolboxes to enhance media development processes. * Stay up to date with emerging analytical tools, omics technologies and scientific advancements to drive hypothesis guided media optimization. * Generate and review technical reports, regulatory filings, source documents, patents and external publications. * Support media preparation protocol transfer to pilot team and support GMP manufacturing tech transfer. * Foster strong partnerships with internal and external stakeholders, proacti
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