All Of Our Groups
healthcare
PrincipalScientist,UpstreamProcessDevelopment
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“Principal Scientist, Upstream Process Development at All Of Our Groups. Skills: Upstream Process Development, cell culture, bioreactors, process optimization, characterization, scale-up, technology transfer. Develop and optimize processes for recombinant therapeutic proteins and genetic medicines. Design and execute experiments to evaluate, optimize, characterize, and troubleshoot processes and equipment”
What You'll Achieve.
supporting program progression from Research to Manufacturing; advance platform capabilities; accelerate progress
Industry & Context.
problem-solving skills; troubleshoot processes and equipment; Develop novel hypotheses, connect insights across fields, and propose experiments beyond the project plan.
lab-based role, Occasional weekend work may be required for sampling or equipment preparation., Physical demands of this job are consistent with a lab environment, Position requires on-site presence, five days per week, 0-10% travel
What They're Looking For.
Must Have
B.S. degree with 6-9 years, or M.S. degree with 3-6 years, of relevant industry degree in chemical engineering, biological engineering, or related discipline., Experience in operating cell culture in shake flasks and small-scale bioreactors., Qualified applicants must be authorized to work in the United States on a full-time basis., written and verbal communication able to communicate with operations staff and management., problem-solving skills, High learning agility
Nice to Have
Ability to work independently and mentor junior scientists in a collaborative, cross-functional environment., Comfort using AI tools (e.g., Claude, Copilot) for analysis and design., Working knowledge of molecular biology, omics, metabolic flux analysis, and PAT., Creativity to identify improvement opportunities and the initiative to implement them., Proven ability to manage multiple priorities and deliver results in a fast-paced, evolving environment., Experience managing external collaborations with CDMOs.
What You'll Do.
Develop and optimize processes for recombinant therapeutic proteins and genetic medicines
Design and execute experiments to evaluate
and troubleshoot processes and equipment
Operate suspension cell culture in shake flasks and small-scale bioreactors
Analyze and interpret data independently
Author technical reports
and regulatory-supporting documentation
Support equipment qualification
and technology transfer of mammalian-based bioprocesses
Evaluate emerging technologies and equipment
Implement automation to streamline analysis
improve visualization
and maintain data integrity
How You'll Work.
Team & Collaboration
works well across functions; works well with external partners (vendors/academia); collaborative, cross-functional environment; Build internal and external networks; Present clear, actionable, scientific insights to project teams and leadership
Communication Scope
written and verbal communication; able to communicate with operations staff and management; Present clear, actionable, scientific insights
Process & Methodology
manage multiple priorities, deliver results in a fast-paced, evolving environment
Full Job Description
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. **Overview:** At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. **Position Summary:** This role is within Bioproduct Research and Development (BR&D), a multidisciplinary organization that develops and optimizes biologically derived products. Upstream Process Development engineers develop and optimize processes for recombinant therapeutic proteins and genetic medicines, including control strategy, characterization, qualification, scale-up, and technology transfer. This is a hands-on, lab-based role supporting program progression from Research to Manufacturing. The successful candidate is self-motivated, analytical, and an effective communicator who works well across functions and with external partners (vendors/academia) to evaluate new technologies and benchmark best practices. **Key Responsibilities:** * Design and execute experiments to evaluate, optimize, characterize, and troubleshoot processes and equipment with minimal guidance. * Operate suspension cell culture in shake flasks and small-scale bioreactors (e.g., Ambr250, 5 L benchtop bioreactor). * Analyze and interpret data independently. * Author tech
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