Principal Scientist
PrincipalScientist-RGMChemistry
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“Principal Scientist - RGM Chemistry at Principal Scientist. Skills: Bioconjugation, Oligonucleotide therapeutics, Analytical techniques, Team leadership. Design and complete experiments to refine linker chemistry. Design and complete experiments to refine payload stability”
What You'll Achieve.
Advance therapeutic pipeline; Advance medicines from bench to preclinical validation
Industry & Context.
Troubleshooting technical challenges
What They're Looking For.
Must Have
PhD in Chemistry, Biochemistry, Molecular Biology, or related field, 5+ years postdoctoral or industry experience in antibody/oligonucleotide conjugation, Validated expertise in bioconjugation, Validated expertise in oligonucleotide therapeutics, Validated expertise in advanced analytical techniques (HPLC, LC-MS, bioassays), Proven leadership of multidisciplinary teams, Successful track record in advancing therapeutic candidates toward preclinical or clinical development
Nice to Have
Publications, Patents in bioconjugation or RNA therapeutics
What You'll Do.
Design and complete experiments to refine linker chemistry
Design and complete experiments to refine payload stability
Design and complete experiments to refine delivery efficiency
Analyze conjugates with HPLC
Lead project stand-ups
Mentor scientists and research associates
Troubleshoot technical challenges in real time
Partner with Process Development and Manufacturing to scale
Scout and evaluate emerging bioconjugation technologies
Scout and evaluate emerging RNA delivery technologies
Propose data-driven innovation projects
Present program updates to senior R&D leadership
Present strategic recommendations to senior R&D leadership
Present program updates to cross-functional partners
Present strategic recommendations to cross-functional partners
How You'll Work.
Team & Collaboration
Multidisciplinary team; Cross-functional partners; Process Development; Manufacturing
Communication Scope
Presenting program updates; Presenting strategic recommendations
Full Job Description
We are looking for a visionary Principal Scientist – RGM Chemistry to lead the discovery, development, and optimization of antibody-oligonucleotide conjugation technologies that power next-generation targeted therapeutics. Sitting at the intersection of bioconjugation chemistry, RNA science, and process innovation, you will set scientific strategy, guide a multidisciplinary team, and translate ground breaking concepts into scalable solutions that advance our therapeutic pipeline. Your deep expertise, collaborative attitude, and passion for mentoring will drive breakthrough medicines from bench to preclinical validation and beyond. **In this role, a typical day might include the following:** \- Designing and completing experiments to refine linker chemistry, payload stability, and delivery efficiency for antibody-oligo conjugates \- Analyzing conjugates with HPLC, LC-MS, and bioassays to ensure purity, identity, and functional potency \- Leading project stand-ups, mentoring scientists and research associates, and troubleshooting technical challenges in real time \- Partnering with Process Development and Manufacturing to scale promising conjugation methods for preclinical supply \- Scouting and evaluating emerging bioconjugation or RNA delivery technologies, then proposing data-driven innovation projects \- Presenting program updates and strategic recommendations to senior R&D leadership and cross-functional partners **This job might be for you if you:** \- Thrive on pushing the boundaries of antibody and oligonucleotide conjugation science \- Enjoy mentoring and developing talent in a collaborative, fast-paced research environment \- Translate sophisticated data into clear, actionable insights and strategic plans \- Demonstrate a strong record of innovation, publications, and/or patents in bioconjugation or RNA therapeutics \- Excel at balancing deep scientific rigor with pragmatic process development and scale-up considerations \- Are motivated by cross-functional
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