Pfizer
Biologics
PrincipalScientist–ProteinFormulation&BiophysicalCharacterization(High-ConcentrationBiologics)
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“Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics) at Pfizer. Skills: Protein formulation, Biophysical characterization, High-concentration biologics. Design and execute experimental studies to develop and. Apply biophysical and physicochemical characterization to assess and”
What You'll Achieve.
Translate insights into scalable solutions; Enhance Pfizer’s drug product capabilities
Industry & Context.
Mechanistic insights; Mitigate key risks; Complex data analysis; Data interpretation
Some travel required, Lab-work required
What They're Looking For.
Must Have
PhD in Pharmaceutics, Pharmaceutical Sciences, Biophysical Sciences, Biochemistry, Chemistry, Biomedical or Chemical Engineering, or related disciplines, 3–5 years relevant experience in biologics formulation, biophysics, or drug product development, Background in protein formulation for parenteral biologics, Hands-on experience with biophysical/analytical characterization techniques and data interpretation, Ability to design and interpret multi-technique characterization studies, Familiarity with parenteral dosage forms and delivery considerations, Ability to analyze complex data and communicate clear, actionable insights
Nice to Have
Industry experience preferred, Demonstrated scientific output (e.g., publications and/or conference presentations) preferred, Expertise in protein design/engineering principles, Expertise in structure-function relationship, Expertise in identification of developability hot spots, Expertise in how molecular attributes influence formulation behavior, Deep understanding of challenges at elevated protein concentrations, Familiarity with interaction parameters (kD, B22), Knowledge of subcutaneous drug delivery fundamentals, Experience with formulation of oligonucleotides, peptides, or other non-mAb modalities is a plus, Experience with molecular modeling, molecular dynamics simulations, machine learning/AI approaches for formulation or protein behavior prediction, QSPR modeling, Formal project leadership experience preferred
What You'll Do.
Design and execute experimental studies to develop and
Apply biophysical and physicochemical characterization to assess and
generate clear insights
and communicate findings
Develop and advance novel formulation strategies and enabling
Build scalable approaches such as experimental workflows
Collaborate with cross-functional teams to implement and integrate
Build collaborations with academic and industry partners
Contribute to external scientific visibility through publications
Contribute to external scientific visibility through conference presentations
Contribute to external scientific visibility through participation in
Collaborate with the internal Device Center of Excellence
Serve as a liaison and technical subject matter
Provide formulation expertise to project teams
Support key development decisions
Contribute scientific input to regulatory documentation
Lead a cross-functional group focused on subcutaneous delivery
Align with key stakeholders
Devise and implement strategies to advance the biologics
Lead focused technical initiatives or platform
How You'll Work.
Team & Collaboration
Cross-functional teams; Cross-functional group; Internal Device Center of Excellence; Project teams
Communication Scope
Communicate findings; Communicate clear insights
Full Job Description
**Principal Scientist – Protein Formulation & Biophysical Characterization (High-Concentration Biologics)** is a hands-on, laboratory-focused, scientific leadership role within a biologics and vaccines formulation group (DPDD- PhRD) for a deeply technical scientist driving innovation in protein formulation and high-concentration biologics. The role focuses on developing and implementing novel formulation strategies and platform approaches to enable high-dose, patient-centric biologic delivery, including subcutaneous administration. The successful candidate will generate mechanistic insights and translate them into scalable solutions that enhance Pfizer’s drug product capabilities. The individual will serve as a technical subject matter expert, contributing across cross-functional teams and building external scientific presence through publications, presentations, and participation in industry collaborations and consortia. **Key Responsibilities** **1) Formulation Science & Characterization** * Design and execute experimental studies to develop and optimize protein formulations across biologic modalities (e.g., mAbs, fusion proteins, bispecifics, antibody-drug conjugates, peptides, etc.) in liquid and lyophilized dosage forms. * Apply biophysical and physicochemical characterization to assess and mitigate key risks (e.g., aggregation, viscosity, stability). * Analyze data, generate clear insights, and communicate findings to scientific teams. **2) Innovation & Technology Development** * Develop and advance novel formulation strategies and enabling technologies for high-concentration biologics. * Build scalable approaches such as experimental workflows, screening methods, and predictive tools that can be applied across programs. * Collaborate with cross-functional teams to implement and integrate new technologies. **3) External Scientific Engagement** * Build collaborations with academic and industry partners to advance formulation science. * Contribute to external sc
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