Lilly Medicine Foundry
Healthcare
PrincipalScientist-ProcessTranslationandExecution
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optimal for Senior candidates.
“Principal Scientist - Process Translation and Execution at Lilly Medicine Foundry. Skills: Process Translation, Process Execution, Clinical Manufacturing, Chemical Engineering. Facilitate transfer of chemical processes. Operate kilo-scale equipment”
What You'll Achieve.
Optimize manufacturing processes; Increase capacity for clinical trial medicines; Reduce costs; Reduce environmental impact; Ensure right-first-time clinical manufacturing; Accelerate manufacturing advancements; Enable operational readiness; Support project delivery; Build site culture
Industry & Context.
Process troubleshooting; Process investigations; Root cause analysis
Work in manufacturing environments, Work in laboratory environments, Support outside normal hours, Nights or weekends support, Limited domestic travel, Limited international travel
What They're Looking For.
Must Have
BS or MS in Chemical Engineering, 4+ years industry experience, Pharmaceutical process development experience, Pilot plant operations experience, Chemical manufacturing experience, Authorized to work in US
Nice to Have
Deep technical interest in Chemical Engineering, Hands-on experience with kilo-scale equipment, Hands-on experience with pilot-scale equipment, Experience with DeltaV, Experience with Dynochem, Experience with Aspen, Experience with electronic lab notebooks, Experience with crystallization development
What You'll Do.
Facilitate transfer of chemical processes
Operate kilo-scale equipment
Troubleshoot kilo-scale equipment
Apply chemical engineering principles
Perform scale-up calculations
Perform equipment sizing
Develop cake filtration models
Predict filtration rate
Predict cake resistance
Predict deliquoring performance
Design filtration wash studies
Apply modeling approaches
Apply semi-empirical approaches
Predict particle size distribution
Control particle size distribution
Receive chemical process
Evaluate safety of procedures
Author technical documents
Review technical documents
Perform definitive lab trials
Perform familiarization reactions
Order process consumables
Stage process equipment
Summarize experimental results
Present experimental results
Make fact-based decisions
Maintain lab notebook
Prepare technical packages
Enable technical transfers
Ensure accurate replication
Identify areas for improvement
Implement new technologies
Implement new procedures
Contribute to process troubleshooting
Support process deviations
Support quality events
Support non-conformances
Identify quality issues
Communicate quality issues
How You'll Work.
Team & Collaboration
Cross-functional collaboration; Collaborate with chemists; Collaborate with safety group; Collaborate with chemists; Collaborate with technicians; Collaborate with quality representatives
Communication Scope
Presenting experimental results
Process & Methodology
Project delivery, Startup, Continuous improvement
Full Job Description
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact. The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase-appropriate control strategies, and ensures right-first-time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.) Through cross-functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long-term business success. In the Foundry Construction and Project Delivery/Startup Phase (2026 to 2028), roles will be fluid and dynamic as we build a new organization, design and implement the necessary systems and business processes required to enable operational readin
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