Gsk

Biopharma

PrincipalScientist,(NMRSpectroscopist)

$235–350k ~AI est. Collegeville, Pennsylvania, United States FULL TIME
Market Sentiment
HIGH DEMAND

Neural analysis suggests this role is
optimal for Senior candidates.

The Brief

“Principal Scientist, (NMR Spectroscopist) at Gsk. Skills: NMR spectroscopy, Structural characterization, Drug discovery, Drug development. Support drug discovery. Support drug development”

Industry & Context.

Biopharma
Problems you'll solve

Solving challenging problems

What They're Looking For.

Must Have

PhD in NMR spectroscopy, Master’s degree with equivalent experience, Experience with solution phase NMR, Apply 1D, 2D, and heteronuclear NMR, Experience with NMR instrumentation hardware, Experience with NMR instrumentation software, Solid state NMR experience, Low field (benchtop) NMR systems experience, Experience building NMR laboratory, Experience maintaining NMR laboratory, Two or more years experience authoring reports, Two or more years experience authoring regulatory dossiers

Nice to Have

5 years experience in field, Masters degree with 10 years experience, Modern NMR pulse sequence programming expertise, AU programming on Bruker spectrometers, Macro programming on Bruker spectrometers, Structure elucidation software experience, Comply with Quality requirements, Comply with Safety requirements, Comply with GSK policies, Comply with GSK procedures, Protect GSK intellectual property, Experience solving challenging NMR problems, NMR application to biologics, NMR application to monoclonal antibodies, Low field NMR applications knowledge, Low field NMR methodology development knowledge, Solid state NMR instrumentation knowledge, Solid state NMR experiments knowledge, Automated sample preparation expertise, Automated acquisition expertise, Automated data analysis expertise, Knowledge of related scientific disciplines, Engage in cross-disciplinary teams, Integrate scientific data, Integrate spectroscopic techniques, Integrate spectrometric techniques, Drug development process experience, Regulatory file authoring experience, GxP requirements experience, Digital Data and Analytics principles knowledge, Digital Data and Analytics tools knowledge, Digital Data and Analytics approaches knowledge

What You'll Do.

Support drug discovery

Support drug development

Perform structural characterization

Characterize new chemical entities

Characterize synthetic intermediates

Characterize impurities

Characterize degradants

Characterize physical form

Develop NMR methodology

Apply NMR to biologics

Maintain NMR laboratory

Support medicinal chemistry

Support process chemistry

Support structural characterization

Support small molecule drugs

Support monoclonal antibodies

Support mass spectrometry

Support biophysical techniques

Support stress testing

Support forced degradation studies

Support development of medicines

Author regulatory dossiers

How You'll Work.

Team & Collaboration

Cross-disciplinary teams; Cross-functional teams

Communication Scope

Communication skills

Full Job Description

Principal Scientist, (NMR Spectroscopist) At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together. Find out more: [Our approach to R&D](https://www.gsk.com/en-gb/innovation/) GSK has an immediate opening for an NMR spectroscopist in research and development at our site in Collegeville, PA. The NMR team is accountable for all NMR applications in support of drug discovery and development from lead identification to marketing authorization applications. This includes structural characterization of new chemical entities, synthetic intermediates, impurities, and degradants, characterization of physical form with solid state NMR, as well as development of NMR methodology for novel applications in biologics. The NMR team maintains seven NMR instruments ranging from 400 MHz to 700 MHz including solid state NMR capability, and also five additional walk-up NMR’s for use within Medicinal Chemistry and Process Chemistry groups. The NMR team sits within a broader, multi-disciplinary analytical group responsible for structural characterization of small molecule synthetic drugs and biologics such as monoclonal antibodies by mass spectrometry, spectroscopy, and other biophysical techniques as well as stress testing/forced degradation studies. Our group supports the development of innovative and quality medicines for patients through cutting-edge analytical science. **Basic Qualifications:** * PhD in NMR spe

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