PrincipalScientistI,AntibodyEngineering

**Job Title: Principal Scientist I, Antibody Engineering** Location: Suzhou, China **Position Summary** We are seeking an exceptional Principal Scientist, Antibody Engineering to join our Biologics Research team in Suzhou. This is a hands-on bench scientist role for a deep technical expert who thrives at the interface of classical antibody engineering and cutting-edge computational approaches. You will lead and execute the engineering of therapeutic antibody candidates — from liability removal and humanization through affinity maturation and developability optimization — while actively applying AI/ML-based tools to accelerate and enhance every stage of the antibody optimization cycle. This position is not primarily managerial. We are looking for a scientist who is equally comfortable overseeing protein science, interpreting developability findings, and deploying a structure-based generative AI model to design next-generation antibody variants. You will be a cornerstone of our antibody engineering capability, driving scientific excellence and platform innovation in a collaborative, fast-paced R&D environment. \--- **Key Responsibilities** **1\. Hands-On Antibody Engineering & Optimization** Execute the full spectrum of antibody optimization with direct bench involvement, from early liability identification through final candidate selection. Perform liability engineering to identify and resolve deamidation, oxidation, isomerization, and aggregation hotspots Lead affinity maturation campaigns using phage display, yeast display, or other directed evolution platforms Execute antibody humanization strategies including CDR grafting, framework selection, and back-mutation analysis Drive developability optimization through biophysical profiling — addressing viscosity, solubility, thermal stability, and polyspecificity liabilities **2\. AI-Aided Protein Optimization & External Partner Collaboration** Serve as the internal champion for AI-driven antibody optimization, working