Sanofi
biopharma
PrincipalScientistCrystallization&ParticleEngineering
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“Principal Scientist Crystallization & Particle Engineering at Sanofi. Skills: Crystallization, Particle Engineering, Small Molecule Development, Process Development, Scientific Leadership. Define and implement the laboratory's scientific strategy in crystallization and particle engineering. Drive the development and optimization of innovative crystallization processes”
What You'll Achieve.
accelerate development timelines; maintain competitive advantage; create competitive advantage for small molecule programs; optimize processes at industrial scale; contribute to publications and patents
Industry & Context.
recognized ability to solve complex scientific problems
What They're Looking For.
Must Have
PhD in Chemistry, Chemical Engineering, Pharmaceutical Sciences, or related field, Solid and recognized expertise in crystallization, solid-state chemistry, or particle engineering for small molecules, developed through a career rich in scientific challenges in the pharmaceutical industry, In-depth expertise in crystallization process development and polymorphism for small molecule APIs across early-stage and late-stage development, Advanced mastery of particle engineering technologies (spray drying, milling, granulation, etc.), Confirmed experience in QbD, PAT, and process optimization for small molecule development, Fluency in English and in French are required
Nice to Have
Experience working on projects spanning from discovery through commercialization, Scientific publications and/or patents in the field, Experience developing proprietary technologies or innovative processes for small molecules, Expertise in crystallization modeling and simulation tools (e.g., molecular dynamics, thermodynamic modeling, process simulation), Familiarity with modeling and computational approaches to predict and optimize crystallization processes
What You'll Do.
Define and implement the laboratory's scientific strategy in crystallization and particle engineering
Drive the development and optimization of innovative crystallization processes
Push technological boundaries by exploring new approaches and methodologies in particle engineering
Leverage modeling and simulation tools to predict crystallization behavior
optimize process parameters
and accelerate development timelines
Actively contribute to laboratory experiments and scientific work
Identify and evaluate polymorphs and crystalline forms
explore new crystallization strategies
Apply and innovate with QbD and PAT principles
Scout and integrate new technologies and scientific methodologies
Develop creative solutions to complex scientific challenges
Develop proprietary technologies and innovative processes
Ensure seamless technology transfer of processes
Collaborate with production teams to adapt and optimize processes at industrial scale
Document and validate processes according to GMP and quality standards
Lead and develop a team of 3-5 highly motivated scientists/engineers
Conduct annual reviews and support scientific skill development
Facilitate team meetings and foster scientific collaboration and collective innovation
Participate in recruiting high-level scientific talent
Manage laboratory budget and optimize resources
Ensure compliance with Sanofi's EHS standards and GMP guidelines
Oversee management and maintenance of state-of-the-art scientific equipment
How You'll Work.
Team & Collaboration
Collaborate closely with Formulation, Analytical Sciences, Chemical Development, and Manufacturing teams at local and global levels; Provide scientific expertise to project meetings and strategic technical committees; Interact with Sanofi's global scientific teams to share innovations and best practices; Collaborative mindset and ability to work in a matrix organization; Foster scientific collaboration and collective innovation within the team
Communication Scope
Excellent scientific communication skills
Process & Methodology
Deliver scientific deliverables on time and according to quality standards
Full Job Description
**Job title:** Principal Scientist Crystallization & Particle Engineering * **Location:** Montpellier, France # **About the Job** As **Principal Scientist** within our R&D team in Montpellier, you'll lead our Crystallization & Particle Engineering Laboratory and drive innovative projects across Sanofi's small molecule portfolio — from early-stage discovery through commercialization. Ready to get started? Are you a recognized expert in crystallization and particle engineering, passionate about scientific innovation and ready to have a direct impact on the development of life-changing small molecule medicines? This role is for you. We are seeking a high-level scientist to lead our Crystallization & Particle Engineering Laboratory in Montpellier. As Scientific Leader, you will drive innovative projects across Sanofi's small molecule portfolio, from early-stage discovery through late-stage development and commercialization. You will develop cutting-edge crystallization and particle engineering processes, push technological boundaries, and become a recognized scientific reference within the global Sanofi community. You will lead a team of 3-5 highly qualified scientists and engineers while remaining deeply involved in the laboratory's scientific activities. You will have real autonomy in defining scientific directions, and your expertise will directly influence development decisions at the global level. Join the engine of Sanofi's mission — where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions. # _**About Sanofi**_ We’re an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives.
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