Sanofi
Biotechnology
PrincipalScientist,BiologicsDiscovery&Innovation
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“Principal Scientist, Biologics Discovery & Innovation at Sanofi. Skills: Biologics Discovery, Antibody Discovery, CRO Management, Platform Expertise. Serve as discovery lead or co-lead on critical. Oversee antigen design and immunization strategy”
What You'll Achieve.
Accelerated program delivery; Tangible program milestones; Critical development milestones; Streamline and accelerate discovery-to-candidate progression
Industry & Context.
Proactive resolution of technical or operational challenges; Creative problem-solving
What They're Looking For.
Must Have
5+ years antibody discovery, Ph.D. in Immunology, Biochemistry, Bioengineering, Deep, hands-on expertise in at least two of the following discovery platforms: phage display, yeast display, ribosome display, single cell cloning, or hybridoma technology, Proven experience in antigen design and immunization strategy, Hit identification and lead selection capabilities, Skilled and experienced in leading or co-leading cross-functional discovery teams
Nice to Have
Extensive industrial or advanced academic research experience, Proven experience in bispecific/multispecific antibody discovery, Nanobody/VHH programs experience, Hands-on experience with bispecific/multispecific antibody discovery formats, Nanobody/VHH discovery workflows experience, Working knowledge of antibody engineering disciplines
What You'll Do.
Serve as discovery lead or co-lead on critical
Oversee antigen design and immunization strategy
Oversee hit identification
Design antigen engineering strategies
Execute antigen engineering strategies
Define clear program objectives
Define success criteria
Define milestone plans
Oversee hybrid discovery workflows
Integrate novel antibody technologies into therapeutic pipelines
Resolve bottlenecks to maintain program momentum
Provide authoritative technical leadership across antibody discovery platforms
Lead single cell cloning workflows campaigns
Optimize single cell cloning workflows
Guide teams on scientific applicability and limitations of
Scan external landscape for breakthrough technologies
Lead discovery campaigns for bispecific and multispecific antibodies
Apply specialized screening and selection strategies
Evaluate emerging modality-specific discovery approaches
Implement emerging modality-specific discovery approaches
Strategically coordinate external CRO partnerships
Define project scopes for CROs
Define deliverables for CROs
Define quality standards for CROs
Define timelines for CROs
Serve as primary interface between internal stakeholders and
Ensure seamless communication with external discovery resources
Ensure alignment of objectives with external discovery resources
Resolve technical or operational challenges with external discovery
Conduct regular performance reviews of CRO partners
Drive continuous improvement with CRO partners
Apply antibody engineering expertise to advance discovery leads
Champion adoption of innovative approaches
Champion AI-driven screening
Champion machine learning-assisted design
Champion automated workflows
How You'll Work.
Team & Collaboration
Cross-functional teams; External CRO resources; External discovery partners; Internal scientific capabilities; CRO deliverables; External partner commitments
Communication Scope
Translate complex discovery science
Process & Methodology
Program management, Project management
Full Job Description
**Principal Scientist, Biologics Discovery & Innovation** **Location:** Suzhou, China **Position Summary** We are seeking an accomplished Principal Scientist with broad biologics knowledge and technical leadership expertise to drive global R&D projects through internal–CRO hybrid models. In this role, you will be a subject-matter expert for biologics discovery, engineering, and relevant technology platforms, validating new approaches and ensuring accelerated program delivery in areas such as oncology, immunology, ophthalmology, or CNS. Success requires managing multidisciplinary teams and external resources, applying advanced scientific and project skills to validate and co-lead biologics programs from concept to key milestones. This is a unique opportunity to operate at the intersection of scientific excellence and strategic execution. You will apply deep domain expertise to evaluate and champion emerging biologics technologies, translating scientific insights into tangible program milestones. Success in this role requires the ability to orchestrate multidisciplinary internal teams alongside external CRO resources, driving biologics programs from early concept through critical development milestones with rigor, agility, and collaborative leadership. **Key Responsibilities** **1\. Antibody Discovery Program Leadership** * Serve as discovery lead or co-lead on critical antibody programs, overseeing the full arc from antigen design and immunization strategy through hit identification, screening, and lead selection. * Design and execute antigen engineering strategies—including recombinant protein design, hapten conjugation, and cell-based immunization approaches—to maximize the quality and diversity of immune responses. * Define clear program objectives, success criteria, and milestone plans to align cross-functional stakeholders and external discovery partners. * Oversee hybrid discovery workflows (internal + external) that integrate novel antibody technologies into t
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