Korro
Biopharmaceutical
PrincipalScientist,AnalyticalSciences
Neural analysis suggests this role is
optimal for Senior candidates.
“Principal Scientist, Analytical Sciences at Korro. Skills: Analytical Sciences, Oligonucleotide therapeutics, Method development, Method validation. Serve as SME for synthetic oligonucleotide-based drug substance. Develop and optimize analytical methods”
Industry & Context.
Troubleshooting; Root cause analysis; OOS investigations; OOT investigations
What They're Looking For.
Must Have
PhD in Analytical, Organic Chemistry, or related field with 3+ years’ or MS with 7+ years or BS with 10+ years of relevant industry experience, 3+ years of hands-on experience in analytical method development for small molecule therapeutics, Expertise in chromatographic (e.g., LC-UV, and LC-MS) and spectroscopic techniques (e.g., UV-Vis), Experience with compendial methods used to release sterile products, Familiarity with HRMS analysis in the identification of DS impurities, Functioning knowledge of the chemical principles of molecular degradation pathways, understanding of cGMP and ICH guidelines for analytical aspects of small molecule sterile products in clinical development, Experience with supporting design and management of stability studies, Managed transfer, qualification, and ideally validation of methods, Supported batch disposition, OOS, OOT, and investigations, Excellent written and verbal communication skills, Ability to work collaboratively in a fast-paced environment, Manage multiple projects simultaneously
Nice to Have
Experience in synthetic oligonucleotide therapeutics is desired, understanding of method validation requirements, compendial method verification, primary and working reference standard qualification, aliquoting, and long-term management
What You'll Do.
Serve as SME for synthetic oligonucleotide-based drug substance
Develop and optimize analytical methods
Support analytical method validation
Support analytical method transfer
Support analytical method troubleshooting
Ensure compliance with cGMP standards
Collaborate with Process/Formulation Development teams
Ensure seamless integration of analytical methods into DS
Interpret complex data
Present complex data to cross-functional teams
Present complex data to senior management
Author technical reports
Author sections of regulatory filings
Assist in managing external analytical collaborations with CROs
Ensure data quality from CROs and CMOs
Ensure timelines from CROs and CMOs are met
Stay current with emerging analytical technologies
Apply innovative solutions to improve method robustness
Apply innovative solutions to improve method efficiency
Support investigations for OOS results
Support root cause analyses for OOS results
Support investigations for deviations
Support root cause analyses for deviations
Support investigations for process failures
Support root cause analyses for process failures
How You'll Work.
Team & Collaboration
Cross-functional teams; External partners; Process/Formulation Development teams; CROs; CMOs
Communication Scope
Written communication; Verbal communication; Technical reports; Regulatory documents
Process & Methodology
Manage multiple projects
Full Job Description
## Description Company Summary: Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro is based in Cambridge, Massachusetts. We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values - Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health. Korro Bio is seeking an experienced analytical scientist to join the growing CMC team. You will focus on management of CMO analytical labs as well as development of analytical methods, characterization of impurities, degradation pathways, and transfer, qualification/validation of analytical methods for synthetic oligonucleotide-based therapies. This role will support and manage - the quality and stability of drug substances and drug products throughout
Applying for this Principal Scientist, Analytical Sciences role?
Most applicants get filtered before a human reads their resume. See if yours makes the cut.
How to Apply on Lever
- Lever uses a streamlined one-page form — apply in under 5 minutes.
- LinkedIn import works well; review parsed data before submitting.
- The cover letter field is optional but visible to reviewers — use it to differentiate.
- Referral codes from employees can significantly boost visibility of your application.
ANONYMOUS · UNFILTERED
What do employees actually say about Korro?
Real rants from real employees. Read before you apply.