PrincipalEngineer

About Pioneering Intelligence Pioneering Intelligence builds on Flagship Pioneering's legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio of AI-first companies. As part of Flagship's integrated model of science, entrepreneurship, and capital, it transforms breakthrough ideas into world-changing companies, elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. The Role Pioneering Intelligence is looking for a Principal Software Engineer to join a small, senior team building the digital and AI platform that powers drug discovery and scientific research across the Flagship Pioneering ecosystem. This is a senior individual contributor role that will report directly to the Vice President of Engineering and operate as the technical authority for one or more product areas — designing systems end-to-end, building hands-on, and engaging directly with the scientists, ML researchers, and strategists who use what you build. This is not a role for engineers who want to be shielded from ambiguity or who need a product manager to translate user needs into tasks. You will own the full technical stack for your product area: from understanding what scientists actually need, through system design and data architecture, to deployment and ongoing reliability. You will work in close partnership with product leadership and ML scientists, but the technical decisions are yours to make and yours to own. The team model is intentionally lean. Each Principal Engineer on this team is a full technical lead for their domain, not one of several engineers on a layered team. You may from time to time coordinate the work of embedded software engineering contractors, but your primary contribution is your own engineering output and technical judgment. The VP of Engineering will set strategy and remove organizational blockers