PrincipalBioinformaticsScientist

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. ### ### The Position We are seeking a highly skilled and experienced Principal Bioinformatics Scientist I specializing in Next Generation Sequencing (NGS) to join our research team. As a Computational Biologist in NGS, you will lead and contribute to cutting-edge projects focused on analyzing and interpreting NGS data, playing a pivotal role in advancing our understanding of complex biological systems, genetic variations, and disease mechanisms. Your expertise and leadership will drive the development and application of innovative computational methods in NGS data analysis. ****The Opportunity:**** * Apply advanced computational methods and algorithms to analyze and interpret NGS datasets, including whole-genome sequencing, exome sequencing, transcriptome sequencing, ChIP-seq, and other relevant NGS applications. Perform quality control, data preprocessing, alignment, variant calling, and annotation. * Utilize your expertise in variant calling and analysis to identify and interpret genetic variations, including single nucleotide variants (SNVs), insertions, deletions, structural variants, and copy number variations. Assess variant functional impact and provide insights into disease mechanisms. * Integrate NGS data with other omics datasets (e.g., transcriptomics, epigenomics) to gain a comprehensive understanding of biological systems. Apply integrative approaches to uncover relationships between genomic alterations, gene expression, and epigenetic modifications. * Develop and optimize computational algorithms, st