PrincipalAISystemsEngineer

Iovance Biotherapeutics aims to be the global leader in innovating, developing and delivering tumor infiltrating lymphocyte (TIL) therapy for people with cancer. We are pioneering a transformational approach to treating cancer by harnessing the ability of the human immune system to recognize and attack diverse cancer cells in each patient. The Iovance TIL platform has demonstrated promising clinical data across multiple solid tumors. We are committed to continuous innovation in cell therapy, including gene-edited cell therapy, which may be a promising option for patients with cancer. Overview This is a senior role responsible for the hands-on design, build, validation, and deployment of Artificial Intelligence (AI) systems at Iovance Biotherapeutics. This role is focused on execution — turning approved use cases into working, validated, production AI systems that deliver measurable business value. This role directly supports Iovance’s strategy to improve overall operational productivity. The ideal candidate is a deeply technical, hands-on senior engineer with demonstrated production experience designing and shipping Large Language Model (LLM) applications, Retrieval-Augmented Generation (RAG) systems, and modern AI integrations. This position works closely with IT leads, business process owners across Manufacturing, Quality, Regulatory Affairs, Clinical, Commercial, G treat evaluation as a first-class engineering deliverable, not an afterthought. Design and implement integrations between AI systems and Iovance enterprise systems using Model Context Protocol (MCP), APIs, and event-driven patterns, applying least-privilege access principles and partnering with IT Security on integration approval. Own and maintain LLM security controls for production AI systems, including input and output guardrails, prompt injection and jailbreak defenses, sensitive data redaction (PII, PHI, Iovance Confidential Information and Intellectual Property), content moderation, and abuse mon