University Health Network
Healthcare
PostdoctoralResearcher
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“Postdoctoral Researcher at University Health Network. Skills: CRISPR/Cas9, Mouse models, Molecular biology, Functional genomics. Design CRISPR/Cas9 screens. Execute CRISPR/Cas9 screens”
What You'll Achieve.
Nominate new strategies; Prevent myeloid malignancy; Treat myeloid malignancy
Industry & Context.
Problem-solving skills
What They're Looking For.
Must Have
PhD within 5 years, MD or DDS within 10 years, Hands-on molecular biology, CRISPR/Cas9 gene editing, CRISPR/Cas9 screening, Design lentiviral vectors, Produce lentiviral vectors, Design retroviral vectors, Produce retroviral vectors, Mouse handling experience, In vivo experimental experience, Flow cytometry experience, Cell sorting experience, Primary hematopoietic cell culture
Nice to Have
Background in oncology, Hematologic malignancies background, Analysis of CRISPR-screen data, Analysis of NGS data
What You'll Do.
Design CRISPR/Cas9 screens
Execute CRISPR/Cas9 screens
Analyze CRISPR/Cas9 screens
Identify synthetic-lethal interactions
Identify genetic interactions
Generate mouse models
Characterize mouse models
Manage mouse colonies
Perform in vivo experiments
Construct lentiviral vectors
Produce lentiviral vectors
Construct retroviral vectors
Produce retroviral vectors
Perform molecular techniques
Perform cellular techniques
Analyze functional genomic datasets
Integrate functional genomic datasets
Analyze next-generation sequencing datasets
Integrate sequencing datasets
Maintain documented records
Adhere to biosafety standards
Adhere to animal-care standards
Prepare presentations
Present findings at lab meetings
Present findings at conferences
Contribute to grant writing
Conceive research directions
How You'll Work.
Team & Collaboration
Computational team; Multidisciplinary team
Communication Scope
Written communication; Verbal communication; Present findings
Full Job Description
UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute, The Michener Institute of Education and West Park Healthcare Centre. As Canada's top research hospital, the scope of biomedical research and complexity of cases at UHN have made it a national and international source for discovery, education and patient care. UHN has the largest hospital-based research program in Canada, with major research in neurosciences, cardiology, transplantation, oncology, surgical innovation, infectious diseases, genomic medicine and rehabilitation medicine. UHN is a research hospital affiliated with the University of Toronto. UHN’s vision is to build A Healthier World and it’s only because of the talented and dedicated people who work here that we are continually bringing that vision closer to reality. [www.uhn.ca](https://www.uhn.ca/) Union: Non-Union Number of Vacancies: 1 New or Replacement Position: Replacement Site: Princess Margaret Cancer Research Tower Department: Research Reports To: Principal Investigator Salary Range: $54,902 - $93,333 Per Year Hours: 37.5 Hours Per Week Shifts: Monday - Friday Status: Temporary Full-time (1-Year Contract) Closing Date: June 24, 2026 Position Summary: A Postdoctoral Researcher position is available in the laboratory of Dr. Steven Chan at the Princess Margaret Cancer Centre. The Chan Laboratory studies the biology of acute myeloid leukemia (AML), leukemic stem cells, and clonal hematopoiesis (CH), with a strong translational focus on discovering and exploiting novel therapeutic vulnerabilities in pre-malignant and malignant myeloid cells. This project will define the genetic and synthetic-lethal interactions of high-risk clonal hematopoiesis mutations, including TP53 and spliceosome (splicing factor) mutations, that drive the progression of C
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