Biohub
scientific discovery
PostdoctoralFellow,Single-CellMethodDevelopment
Neural analysis suggests this role is
optimal for Mid+ candidates.
“Postdoctoral Fellow, Single-Cell Method Development at Biohub. Skills: single-cell method development, high-throughput single-cell genomics platform, microfluidics, droplet chemistry, bead-based assay design, genomic data analysis. Lead assay and workflow development. Design, optimize, and scale a high-throughput single-cell workflow for challenging biological samples”
Industry & Context.
troubleshooting challenging workflows; computational analysis integrating machine learning and AI
What They're Looking For.
Must Have
PhD in Molecular Biology, Biochemistry, Biomedical Engineering, Bioengineering, or a related field, research track record and evidence of productivity in relevant areas of single-cell biology, genomics, bioengineering, or assay development, 2 - 4 years of demonstrated expertise in single-cell method development, Proven ability to develop, optimize, and implement complex molecular or genomic assays, hands-on experimental skills and a track record of troubleshooting challenging workflows, Ability to work independently and effectively in a collaborative, multidisciplinary environment
Nice to Have
Experience with RNA biology, transcriptional regulation, or functional genomics, Experience developing or applying microfluidic and bead-based workflows for single-cell applications, Familiarity with CRISPR perturbation, functional genomics screens, or chemical perturbation experiments, Experience working with patient-derived samples, biopsies, or organoid models, Computational fluency in genomic data analysis and familiarity with tools such as STAR, Bowtie, Seurat, Scanpy, or related pipelines, Experience integrating multi-modal single-cell datasets, Comfort working in Linux/HPC environments and collaborating closely with computational scientists
What You'll Do.
Lead assay and workflow development
and scale a high-throughput single-cell workflow for challenging biological samples
Develop and refine workflows involving cell or nuclei handling
droplet microfluidics
and library preparation
Systematically benchmark assay performance
Execute molecular and cellular workflows
Perform molecular biology and genomics experiments
including sample preparation
nucleic acid isolation
next-generation sequencing library preparation
and assay optimization
Adapt and implement protocols for patient biopsies
and 3D organoid systems
reproducible methods for low-input
biologically complex samples
Integrate perturbation-based approaches
Combine the platform with genetic and chemical perturbation strategies
including CRISPR-based perturbations and drug treatments
Evaluate compatibility with complementary multi-omic profiling approaches
How You'll Work.
Team & Collaboration
Working closely with computational biologists and interdisciplinary collaborators; highly collaborative and rigorous research environment; collaborating closely with computational scientists
Full Job Description
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. The Team Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’ s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here. Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Our Vision Pursue large scientific challenges that cannot be pursued in conventional environments Enable individual investigators to pursue their riskiest and most innovative ideas Facilitate research by scientists and clinicians at our home institutions and beyond We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease. The Laboratory of Immunogenomics at Biohub studies the non-coding regulatory genome to understand and address immune dysfunction in diseases like cancer, autoimmune disorders, and aging. We focus on enhancers—non-coding, highly cell–type–specific transcriptional regulatory elements—and their role in shaping immune responses. We develop and utilize genomic technologies, including bulk and single-cell nascent RNA sequencing, genome editing, imm
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