Biohub SF, LLC

Biomedical research

OpticalEngineer,AdvancedLightSheetMicroscopy

$165–225k ~AI est. San Francisco, California, United States Remote Friendly
Market Sentiment
HIGH DEMAND

Neural analysis suggests this role is
optimal for Mid+ candidates.

The Brief

“Optical Engineer, Advanced Light Sheet Microscopy at Biohub SF, LLC. Skills: Light sheet microscopy, Optical engineering, Hardware control, Automation. Design, prototype, implement, and optimise custom subsystems. Integrate mechanical, thermal, fluidic, optical, and electronic components”

Industry & Context.

Biomedical research
Problems you'll solve

Troubleshoot complex mechanical systems; Troubleshoot complex electrical systems; Troubleshoot complex software systems

What They're Looking For.

Must Have

Master of Science, or PhD degree, at least 5 years practical engineering skills, at least 4 years solid working knowledge of electronics, at least 3 years CAD design experience, programming experience in C/C++/Rust, Proven experience developing hardware control scripts, Proven ability to troubleshoot complex systems, communication skills, collaborative ability to work effectively

Nice to Have

Experience with C/C++/Rust desired, Knowledge and experience in light-sheet microscopy, Experience or interest in integrating Adaptive Optics, Experience with feedback control systems, Experience designing or integrating thermal control, Experience and deep understanding of low-level coding, Familiarity with high-performance computing concepts, Familiarity with Linux-based systems, Familiarity with optical metrology, Experience working in a biological or life sciences research environment

What You'll Do.

and optimise custom subsystems

and electronic components

Develop modular hardware control software

Interface with cameras

Design and implement automated imaging protocols

Incorporate feedback loops

Implement new features and capabilities

Contribute to data acquisition workflows

Handle large-scale imaging datasets

Document system architectures

Document mechanical designs

Document assembly procedures

How You'll Work.

Team & Collaboration

Multidisciplinary team; Computer scientists; Optical engineers; Biologists; Scientists; Bioengineers

Full Job Description

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere. The Team Biohub is a 501(c)(3) biomedical research organization building the first large-scale scientific initiative combining frontier AI with frontier biology to solve disease. We build the technology to help scientists around the world use AI-powered biology to study how cells operate, organize, and work as part of systems to understand why disease happens and how to correct it. With our compute capacity, AI research and engineering, and state-of-the-art technology for measuring, imaging, and programming biology, we are enabling scientists worldwide to use AI-powered biology to advance our understanding of human health. Through our multi-dimensional imaging program, we build imaging tools that capture life across scales — from single proteins to whole organisms — revealing how proteins and cells function, communicate, and assemble into living systems. These observations are laying the groundwork for a new generation of AI models that can predict cellular behavior and guide the development of better treatments for widespread diseases. You can learn more about our work here. Our work brings together three powerhouse universities - Stanford, UC Berkeley, and UC San Francisco - into a single collaborative technology and discovery engine. Our Vision Pursue large scientific challenges that cannot be pursued in conventional environments Enable individual investigators to pursue their riskiest and most innovative ideas Facilitate research by scientists and clinicians at our home institutions and beyond We a

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