MemberoftheTechnicalStaff,Cheminformatics

The Role Output has built a biological reasoning model that understands biology at the scale and complexity life actually operates. Our model independently learned the principles of molecular interactions, opening up drug treatments that were previously impossible. We're already generating therapies that traditional approaches cannot reach. The hardest problems in both AI and biology are being solved here, and there is room for you to own one. Output is currently in stealth, operated by a team of repeat founders and biotech veterans with multiple exits in AI x Bio, and backed by top-tier VCs including Y Combinator. You accelerate the path from a generated molecule to a synthesized compound. This role continues to build the models and computational methods that optimize Output's molecular generation for practical chemistry. - You will continue developing and training models that incorporate knowledge of chemical synthesis routes and reactions, steering molecular generation toward molecules that are efficient to synthesize - You will build scalable computational tools and methods that evaluate synthetic feasibility across generated molecular libraries, systematically and at scale - You will interpret model inputs and outputs in chemistry terms, translating between the language of generative AI and the language of synthesis - You will work with the drug discovery and model teams, bringing chemistry expertise to molecular evaluation and candidate prioritization - You will build and maintain cheminformatics pipelines for molecular analysis, property calculation, and candidate assessment About You You have a PhD in chemistry, computational chemistry, cheminformatics, or a related field with 2+ years of post-doctoral or industry research experience, or a Master's degree with 5+ years of hands-on experience in computational chemistry or cheminformatics - You have deep understanding of organic chemistry, synthetic routes, and chemical reactions - You have experience training