Bicycle Therapeutics
Healthcare
Manager,TechnicalOperations
Neural analysis suggests this role is
optimal for mid candidates.
“Manager, Technical Operations at Bicycle Therapeutics. Skills: laboratory operations, HSE leadership, asset management, collaboration. ensuring the smooth, safe, and efficient functioning of our research and development labs. overseeing a wide range of activities, from health and safety compliance to strategic asset management”
Industry & Context.
solve complex organisational challenges, such as developing the safety framework for introducing novel high-potency materials or designing a cross-site asset management strategy.
participate as a member of the out-of-hours and business continuity teams
What They're Looking For.
Must Have
A proven track record of leading laboratory operations and health & safety within a dynamic academic or biopharmaceutical industry setting., Deep expertise in laboratory HSE principles and governance, ideally evidenced by a nationally recognised certification (e.g., NEBOSH), membership of relevant societies and experience acting as a Biological or Chemical Safety Officer., Demonstrable experience developing and executing strategies for laboratory asset management, including the procurement and maintenance of high-value scientific equipment., Broad knowledge of the requirements for handling regulated materials, such as human-derived tissues, high-potency compounds, or genetically-modified organisms., A collaborative and influential leader with experience managing relationships with external partners and embedding a positive culture of safety and operational excellence.
Nice to Have
Recent experience acting as a Radiation Protection Supervisor (RPS) would be a significant advantage., Previous hands-on experience working in a laboratory environment is highly desirable.
What You'll Do.
and efficient functioning of our research and development labs
overseeing a wide range of activities
from health and safety compliance to strategic asset management
Lead and manage all laboratory-related health
and environment (HSE) matters.
Liaise with lab-active staff and senior leadership to ensure new capabilities are forecast and prepared for.
Ensure lab-working contractors are suitably certified and permitted to work on site.
Lead lab-safety related teams
including First Aid and Spill Teams
to ensure coordinated and appropriate responses to issues.
Ensure updates to lab safety legislation are identified and implemented
Drive the laboratory HSE strategy
ensuring robust safety protocols
occupational health and compliance measures are embedded in all lab activities.
Serve as the primary liaison between scientific teams and leadership for forecasting and safely implementing new technical capabilities.
Lead the lab safety governance
working with the site's EHS chair and committee
ensuring that legislative updates are identified and implemented effectively.
Serve as the key safety lead for regulated materials
including providing oversight as a Radiation Protection Officer (RPO) as applicable
and working with external advisors.
Oversee the full lifecycle of laboratory assets
partnering with Procurement to manage inventory
preventative maintenance schedules
and reactive repairs to ensure scientific continuity and compliance.
Working with our procurement team and vendors
manage laboratory assets
preventative and reactive maintenance
to ensure safety and compliance.
Lead and liaise with internal science teams to develop the strategy for sourcing laboratory equipment and supplies
managing key vendor relationships to maximize value
safety and innovation.
Ensure a consistent and effective lab inspection program is performed and lead incident reviews to guarantee that learnings are captured and applied across the organisation.
Develop and implement training programs for all laboratory personnel on critical equipment
and operational routines.
Manage and foster relationships with external research partners (e. g.
academic institutions) to ensure Bicycle assets are maintained and staff operate safely and compliantly at third-party sites.
Build and maintain pathways for Bicycle staff to obtain access to third party facilities and activities
whilst satisfying legal and contractual obligations
Participate as a member of the out-of-hours and business continuity teams
addressing urgent laboratory issues that arise outside of normal working hours.
How You'll Work.
Team & Collaboration
Liaise with lab-active staff and senior leadership; Lead lab-safety related teams; Serve as the primary liaison between scientific teams and leadership; Lead and liaise with internal science teams; Manage and foster relationships with external research partners (e.g., CROs, academic institutions); Build and maintain pathways for Bicycle staff to obtain access to third party facilities and activities; Participate as a member of the out-of-hours and business continuity teams; Develop future leaders within your team and the wider operational community
Process & Methodology
oversee a complex portfolio of operational programs, from asset lifecycle management to the entire laboratory HSE system
Full Job Description
Bicycle Therapeutics is a clinical-stage pharmaceutical company developing a novel class of medicines, referred to as Bicycle® molecules, for diseases that are underserved by existing therapeutics. Bicycle molecules are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycle molecules attractive candidates for drug development. The company is evaluating zelenectide pevedotin (formerly BT8009), a Bicycle® Drug Conjugate (BDC®) targeting Nectin-4, a well-validated tumor antigen; BT5528, a BDC molecule targeting EphA2, a historically undruggable target; and BT7480, a Bicycle Tumor-Targeted Immune Cell Agonist® (Bicycle TICA®) targeting Nectin-4 and agonizing CD137, in company-sponsored clinical trials. Additionally, the company is developing Bicycle® Radioconjugates (BRC®) for radiopharmaceutical use and, through various partnerships, is exploring the use of Bicycle® technology to develop therapies for diseases beyond oncology. Bicycle Therapeutics is headquartered in Cambridge, UK, with many key functions and members of its leadership team located in Lexington, Massachusetts, USA. For more information, visit [bicycletherapeutics.com](https://cts.businesswire.com/ct/CT?id=smartlink&url=http%3A%2F%2Fwww.bicycletherapeutics.com%2F&esheet=54319804&newsitemid=20250905119859&lan=en-US&anchor=bicycletherapeutics.com&index=1&md5=2ceddbc5724111d13050dd110c77151b) Culture is key and all Bicycle employees actively embrace and role model our company values: * We are Adventurous. We believe it’s the way to deliver extraordinary results for our patients. * We are Dedicated to our Mission. You can’t change the world if you don’t have determination. * We are One Team. We only succeed when we work together. The Manager, Technical Operations will be a critical member of the Laboratory & Facilities team, responsible fo
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