Xenon Pharmaceuticals

Biotech

Manager/SeniorManager,TrialOperations

$140–195k Boston, Massachusetts, United States; Pawtucket, Rhode Island, United States FULL TIME
Market Sentiment
HIGH DEMAND

Neural analysis suggests this role is
optimal for Manager candidates.

The Brief

“Manager/Senior Manager, Trial Operations at Xenon Pharmaceuticals. Skills: Trial operations leadership, Clinical trial management, Vendor management, Budget oversight. Provide clinical trial management leadership. Collaborate with cross-functional team members”

What You'll Achieve.

Deliver critical milestones on time; Deliver critical milestones within budget

Industry & Context.

Biotech
Problems you'll solve

Risk assessment; Mitigation strategies; Contingency planning

Eligibility Requirements

5-10% travel

What They're Looking For.

Must Have

Project management experience, Organizational skills, Ability to work independently, Ability to work collaboratively, Good judgement, Flexibility, Detail oriented

Nice to Have

Previous experience with CTA and IND submissions preferred

What You'll Do.

Provide clinical trial management leadership

Collaborate with cross-functional team members

Coordinate proposal evaluation

Provide input into selection and contracting

Manage contracted service providers

Lead investigator and site selection

Review and oversee study budgets

Manage study timelines

Conduct risk assessments

Develop mitigation strategies

Develop contingency planning

Communicate with internal/external teams

Mitigate/resolve challenges

Participate in clinical trial operations

Coordinate clinical trial protocols

Write clinical trial protocols

Review clinical trial protocols

Finalize clinical trial protocols

Coordinate consent forms

Finalize consent forms

Coordinate study plans

Coordinate safety reviews

Review safety reviews

Finalize safety reviews

Coordinate essential regulatory documents

Write essential regulatory documents

Review essential regulatory documents

Finalize essential regulatory documents

Share trial conduct best practices

Implement trial conduct best practices

Oversee adherence to regulations

How You'll Work.

Team & Collaboration

Cross-functional team members; Internal/external teams; Multidisciplinary team

Communication Scope

Verbal communication; Written communication

Process & Methodology

Project management, Timeline management, Budget management, Milestone delivery

Full Job Description

Who We Are: Xenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. What We Do: We are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neur

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