Lilly
healthcare
LeadChemistRNAiDrugDiscovery
“Lead Chemist - RNAi Drug Discovery at Lilly. Skills: RNAi drug discovery, oligonucleotide chemistry, molecular biology, pharmacology, delivery technologies. Critical evaluation of scientific and business opportunities. Design and execution of novel RNAi therapeutics”
Industry & Context.
analytical and problem-solving skills
Up to 10-15% domestic and international travel
What They're Looking For.
Must Have
PhD or Master’s in Chemistry or related field, 7+ years of oligonucleotide chemistry, lead optimization and design experience, 10+ years of drug discovery experience (can include post doc experience), 3 patents or patent applications demonstrating scientific leadership in oligonucleotide therapeutics
Nice to Have
Proven track record managing cross-functional teams and projects, Experience managing external CRO relationships and resources related to oligonucleotide research, Deep understanding of RNAi mechanisms, delivery technologies, pharmacology, and drug development processes, leadership abilities, strategic thinking, and entrepreneurial mindset, Excellent communication and interpersonal skills with ability to influence across organizations, Experience with RNAi screening technologies, sequence selection, human-relevant pharmacology models, purification and formulation best practices and automation platforms, Knowledge in area of oligonucleotide relevant tissue delivery and conjugation chemistry, Knowledge of therapeutic areas relevant to RNAi medicines, Proven track record of successful collaboration within drug discovery organizations, analytical and problem-solving skills, Experience in biotech partnership models or early-stage drug discovery environments
What You'll Do.
Critical evaluation of scientific and business opportunities
Design and execution of novel RNAi therapeutics
Partnership with Lilly Genetic Medicines LGM
Collaborate with external partners to critically evaluate opportunities for RNAi innovation
Design and execute RNAi discovery projects
Lead and consult regarding siRNA/ASO candidate screening
and lead optimization
Oversee in vivo drug candidate testing with ATP partners
Translate scientific and portfolio needs into an RNAi innovation roadmap
Prioritize opportunities that impact molecule quality
and probability of technical success
Systematically scan internal and external landscapes for RNAi innovation and build scientific cases for licensing
Coordinate pilot execution across internal and external partners
Partner with discovery operations
and finance to transition successful pilots into routine capabilities
Lead and participate in due diligence of early-stage RNAi technology partners
Manage external biotech and CRO relationships
and maintain productive partnerships with biotech collaborators and technology providers
Represent Lilly in external meetings and conferences
Serve as scientific ambassador for ExploR&D's RNAi capabilities
How You'll Work.
Team & Collaboration
Collaborate with external partners; Partner with Lilly Genetic Medicines LGM; Work with leadership; Coordinate pilot execution across internal and external partners; Partner with discovery operations, digital/IT, procurement, and finance; Manage external biotech and CRO relationships; Build workplans, execute, and maintain productive partnerships with biotech collaborators and technology providers; Represent Lilly in external meetings and conferences
Communication Scope
Excellent communication and interpersonal skills with ability to influence across organizations
Process & Methodology
Project Execution, Portfolio Management, Program Execution
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