Recursion
biotech
HeadofDMPK
“Head of DMPK at Recursion. Skills: DMPK strategy, Predictive ADME models, Small molecule DMPK, IND submission requirements, PK/PD modeling. Lead the DMPK strategy to transition internal and partnered programs from early hit-identification through to IND-enabling studies and early clinical development. Define and execute the overarching DMPK strategy for a diverse therapeutic area portfolio”
What You'll Achieve.
Transition our internal and partnered programs from early hit-identification through to IND-enabling studies and early clinical development; Ensure robust human dose projections, DDI assessments, and supporting translational PK/PD strategies; Transforming how we prioritize compounds and de-risking the portfolio; Ensure high-quality data and timely delivery
Industry & Context.
Computational models; Predictive ADME models; De-risking the portfolio
What They're Looking For.
Must Have
PhD (or equivalent) in Pharmacokinetics, Drug Metabolism, Pharmacology, or a related field, Proven track record of moving multiple programs from Discovery into Development (typically 15+ years) in the pharmaceutical or biotech industry, Deep expertise in small molecule DMPK, Intimately familiar with IND submission requirements and have a history of successfully navigating regulatory interactions, Expertise in in vitro & in vivo ADME, Expertise in contemporary PK/PD modeling, Experience with human PK and efficacious dose prediction
Nice to Have
Experience with emerging modalities (e.g. peptides, ADCs, proximity-inducing therapeutics), Experience with related modalities (ADCs, proximity-inducing or peptides), Experience extending to the properties and data sets commensurate with CNS exposure (or conversely restricting exposure to peripheral tissues)
What You'll Do.
Lead the DMPK strategy to transition internal and partnered programs from early hit-identification through to IND-enabling studies and early clinical development
Define and execute the overarching DMPK strategy for a diverse therapeutic area portfolio
Ensure high degree of scientific excellence as programs move from early discovery into development
Partner with Data Science and ML teams to refine our predictive ADME models
Act as a strategic subject matter expert for high-stakes external partnerships
Develop and lead a high-performing team
Ensure that DMPK insights are integrated into the earliest stages of target validation and lead optimization
How You'll Work.
Team & Collaboration
Partner with Data Science and ML teams; Collaborate with internal scientific leaders and external counterparts; A critical component of multidisciplinary project teams; A critical partner to Toxicology, Translation and Design; Value 'One Team' over silos; Known for strong, transparent working relationships and the ability to influence cross-functional stakeholders; True cross-functional collaboration is about trust, clarity, humility, and impact
Communication Scope
Transparency
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