Roche
Pharmaceutical
DMPK-PDProjectLeader(2-yeartemporaryposition)
Neural analysis suggests this role is
optimal for Mid candidates.
“DMPK-PD Project Leader (2-year temporary position) at Roche. Skills: DMPK, PK/PD, Modeling & Simulation, AI/ML. Lead drug design and optimization strategies. Lead compound profiling for DMPK aspects”
What You'll Achieve.
providing the right drug at the right dose to patients safely with an efficacious benefit; defining and delivering clear outcomes
Industry & Context.
address or escalate issues effectively
2-year temporary position
What They're Looking For.
Must Have
PharmD or PhD in Pharmaceutical Sciences, Pharmacology, or Bioengineering, over 5 years of industry experience in a pharmacokinetic-related field, deep expertise in discovery, early PK characterization, distribution, and PKPD across various modalities, solid foundation in pharmacology and physiology, hands-on experience with modeling and simulation, proficiency in applying Artificial Intelligence (AI) Machine Learning (ML) to DMPK strategy, excellent understanding of PK/PD, proven leadership experience to guide complex projects, accountable for defining and delivering clear outcomes, ability to transcend organizational boundaries to address or escalate issues effectively, inclusive, authentic leader who actively seeks diversity and fosters a high-trust environment
Nice to Have
mastery of tools like Phoenix, Berkeley Madonna, GastroPlus, or SimCyp
What You'll Do.
Lead drug design and optimization strategies
Lead compound profiling for DMPK aspects
Provide support to early discovery teams
Develop translational strategies for clinical evaluation
Execute fundamental M&S activities
Prepare and deliver scientific assessments
Implement biomarker and bioanalytical strategies
Facilitate transparent
data-driven decision-making
How You'll Work.
Team & Collaboration
Collaborate closely with therapeutic areas; Implement biomarker and bioanalytical strategies in close collaboration with key partners; Facilitate transparent, data-driven decision-making processes within project teams and squads; Cultivate and maintain trustful professional relationships with both internal and external stakeholders; Collaborative teamwork
Communication Scope
communication skills
Process & Methodology
guide complex projects
Full Job Description
At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters. ### ### The Position In Roche’s[ _Pharmaceutical Research and Early Development organization (pRED)_](https://www.roche.com/innovation/structure/pred/) , we make transformative medicines for patients to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. pRED's Pharmaceutical Sciences (PS) group enables discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines. PS supports discovery and development across the whole value chain from target assessment to on-market and beyond. ## **The Opportunity** As part of the Translational DMPK-PD and Clinical Pharmacology chapter, you will focus on providing the right drug at the right dose to patients safely with an efficacious benefit. You will collaborate closely with therapeutic areas to convert hypotheses into innovative medicines, driving nonclinical strategies to bring forward the best clinical candidates for specific indications. Your Impact & Responsibilities: * Strategy & Design: Lead drug design and optimization strategies and compound profiling for all Drug Metabolism and Pharmacokinetics (DMPK) aspects,
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