Company
Biotech
Director/Sr.Director,OligonucleotideTranslationalScience
Neural analysis suggests this role is
optimal for Director candidates.
“Director/Sr. Director, Oligonucleotide Translational Science. Skills: Oligonucleotide drug development, IND-enabling studies, Preclinical pharmacology, DMPK. Lead design of IND-enabling preclinical studies. Contribute to execution of preclinical studies”
What You'll Achieve.
Support program progression; Advance program; Inform portfolio strategy; Shape IND-enabling strategies; Influence pipeline progression; Influence clinical translation
Industry & Context.
Data-driven decision-making
Occasional travel
What They're Looking For.
Must Have
PhD in pharmacology, molecular biology, biochemistry, or related scientific discipline, 10+ years of experience in oligonucleotide drug development, Direct involvement in IND-enabling programs, Demonstrated hands-on expertise in preclinical pharmacology and DMPK/ADME studies, Proven experience contributing to IND submissions, Understanding of oligonucleotide therapeutic mechanisms, Experience designing, managing, and interpreting in vitro and in vivo studies, Demonstrated ability to oversee CROs and external partners, Analytical skills to interpret complex biological datasets, Excellent scientific communication skills
Nice to Have
Experience with conjugated oligonucleotide platforms, Exposure to bioanalytical methodologies, Prior experience in fast-paced biotech or small-company environments
What You'll Do.
Lead design of IND-enabling preclinical studies
Contribute to execution of preclinical studies
Interpret IND-enabling preclinical studies
Drive integration of DMPK and pharmacokinetic data
Connect PK/PD findings with safety and efficacy outcomes
Lead evaluation of preclinical safety data
Identify scientific gaps in IND packages
Recommend follow-up mechanistic studies
Recommend follow-up pharmacology studies
Recommend follow-up safety studies
Provide strategic input into oligonucleotide design
Oversee CRO and external partner studies
Provide study design input
Validate final deliverables
Ensure scientific rigor across bioanalytical datasets
Ensure scientific rigor across pharmacology datasets
Contribute to IND-enabling submissions
Integrate preclinical pharmacology data into regulatory packages
Integrate DMPK data into regulatory packages
Integrate safety data into regulatory packages
Partner cross-functionally with chemistry teams
Partner cross-functionally with toxicology teams
Partner cross-functionally with translational teams
Partner cross-functionally with clinical teams
Communicate complex scientific findings to governance forums
Communicate complex scientific findings to leadership stakeholders
How You'll Work.
Team & Collaboration
Cross-functionally with chemistry; Cross-functionally with toxicology; Cross-functionally with translational; Cross-functionally with clinical teams; With governance forums; With leadership stakeholders
Communication Scope
Scientific communication; Presenting to teams; Presenting to governance bodies
Full Job Description
## Accountabilities Lead and/or directly contribute to the design, execution, and interpretation of IND-enabling preclinical studies for oligonucleotide programs, including pharmacology, efficacy, MoA, PK/PD, and immunogenicity assessments. Drive integration of DMPK and pharmacokinetic data, including biodistribution, tissue uptake, exposure-response relationships, and durability of effect. Collaborate with DMPK and translational teams to connect PK/PD findings with safety and efficacy outcomes across systemic and tissue compartments. Lead evaluation of preclinical safety data with a focus on off-target effects, therapeutic index, and dose-limiting toxicity risk assessment. Identify scientific gaps in IND packages and recommend follow-up mechanistic, pharmacology, or safety studies to support program progression. Provide strategic input into oligonucleotide design, including chemistry, modifications, and conjugation approaches such as GalNAc-siRNA or antibody-oligo constructs. Oversee CRO and external partner studies, including protocol review, study design input, data interpretation, and final deliverable validation. Ensure scientific rigor and consistency across bioanalytical and pharmacology datasets generated through external vendors and internal teams. Contribute directly to IND-enabling submissions by integrating preclinical pharmacology, DMPK, and safety data into cohesive regulatory packages. Partner cross-functionally with chemistry, toxicology, translational, and clinical teams to support data-driven decision-making and program advancement. Communicate complex scientific findings clearly to governance forums and leadership stakeholders to inform portfolio strategy. Requirements Ph.D. in pharmacology, molecular biology, biochemistry, or a related scientific discipline, or equivalent advanced degree with substantial industry experience. 10+ years of experience in oligonucleotide drug development, with direct involvement in IND-enabling programs (siRNA and/or
Applying for this Director/Sr. Director, Oligonucleotide Translational Science role?
Most applicants get filtered before a human reads their resume. See if yours makes the cut.
How to Apply on Lever
- Lever uses a streamlined one-page form — apply in under 5 minutes.
- LinkedIn import works well; review parsed data before submitting.
- The cover letter field is optional but visible to reviewers — use it to differentiate.
- Referral codes from employees can significantly boost visibility of your application.
ANONYMOUS · UNFILTERED
What do employees actually say about this company?
Real rants from real employees. Read before you apply.