Vertex Pharmaceuticals
Biotechnology
Director-HeadofMolecularProfiling
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“Director-Head of Molecular Profiling at Vertex Pharmaceuticals. Skills: Molecular Profiling, Immunology Research, AI/ML, Leadership. Establish and lead Molecular Profiling capabilities. Ensure alignment with Vertex’s strategic goals”
What You'll Achieve.
Identify, validate and prioritize therapeutic targets; Advance our understanding of human biology and disease; Nominate novel immunology targets
Industry & Context.
Solving complex problems
What They're Looking For.
Must Have
Ph.D. in cellular biology, biochemistry, biophysics, or related disciplines, 10+ years of relevant post-doctoral experience, Expertise in spatial transcriptomics, CYTOF, single-cell sequencing, and proteomics, Experience in complex data analysis, Application of AI/ML methods to derive novel biological insights, Leadership skills with a track record of building and managing high-performing teams, Excellent communication and presentation skills, Ability to effectively collaborate across functional groups, Present to senior leadership, Self-motivated, organized, and adept at solving complex problems, Commitment to transforming the lives of people with serious diseases
Nice to Have
Experience in immunology research, Deep understanding of immune system biology, Experience leading cross-functional teams, Managing external partnerships
What You'll Do.
Establish and lead Molecular Profiling capabilities
Ensure alignment with Vertex’s strategic goals
Develop and execute a strategic vision
Identify and prioritize technology investments
Collaborate with partner technology teams
Build and lead a high-performing team of scientists
Foster a culture of innovation
Leverage clinical samples to generate novel biological insights
Identify high-priority targets and pathways
Investigate immunology indications
Collaborate with the biomarker team
Execute on Vertex’s biomarker strategy
Collaborate with Data and Computational Sciences
Implement advanced AI/ML approaches
and computational teams
Nominate novel immunology targets
Direct single-cell Multiomics atlases
Direct ML models for data-driven target prioritization
Prioritize targets across autoimmune disease cohorts
Serve as a key member of the Seattle
Contribute to the overall strategy and success of
Act as a leader on interdisciplinary project teams
Drive scientific innovation
Ensure alignment with organizational goals
Identify and establish external collaborations
Enhance Molecular Profiling capabilities
and progress to senior leadership
Present to other stakeholders
How You'll Work.
Team & Collaboration
Partner technology teams; Biomarker team; Data and Computational Sciences; Interdisciplinary project teams; Senior leadership; External collaborations; Academic institutions; Biotech companies
Communication Scope
Presentation skills; Senior leadership presentations
Full Job Description
**Job Description** Vertex Pharmaceuticals is seeking a highly motivated and innovative scientist to join our growing immunology research site in Seattle as the Director-Head of Immune Cell Profiling. This leadership role offers a unique opportunity to shape the future of immunology research by building and leading a cutting-edge Molecular Profiling team. The successful candidate will drive strategy, develop advanced research capabilities, and lead a team of scientists to uncover novel biological insights in order to identify, validate and prioritize therapeutic targets. In addition, they will develop and execute a strategy for reverse translation optimally enabling serial innovation for immunological indications in line with Vertex’s strategic goals The Molecular Profiling group will leverage state-of-the-art technologies, including spatial transcriptomics, single-cell RNA/ATAC sequencing, CYTOF, and state of the art proteomics. In close collaboration with the biomarker group the molecular profiling group forms the basis for biomarker discovery. In partnership with the Data & Computational Science group they will be integrating AI/ML-driven data analysis to advance our understanding of human biology and disease. The Head of Molecular Profiling will also play a pivotal role in fostering external collaborations with academic and industry partners to accelerate innovation and expand capabilities. **Key Responsibilities** * Establish and lead Molecular Profiling capabilities at the Seattle research site, ensuring alignment with Vertex’s strategic goals. * Develop and execute a strategic vision for the Molecular Profiling group, including identifying and prioritizing technology investments in collaboration with partner technology teams. * Build and lead a high-performing team of scientists, fostering a culture of innovation, collaboration, and scientific excellence. * Leverage clinical samples to generate novel biological insights and identify high-priority targets and
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