Sanger Institute
ComputationalPostdoctoralFellow-SpatialGenomics
Neural analysis suggests this role is
optimal for Mid+ candidates.
“Computational Postdoctoral Fellow - Spatial Genomics at Sanger Institute. Skills: Spatial genomics, Data integration, Mutation calling. Analyse spatial genomics datasets. Develop methods to call somatic mutations”
What They're Looking For.
Must Have
PhD in computational biology, Genomics experience, Data processing experience, High-throughput data analysis experience, Proficiency in R, Proficiency in Python, Proficiency in Bash, Time management skills, Organizational skills, Ability to meet deadlines, Commitment, Problem-solving skills, Meticulous attention to detail, Ability to summarise complex information, Ability to communicate concisely, Ability to communicate logically, Inclusivity, Respect for all
Nice to Have
PhD awarded within 6 months, Experience in managing large datasets, Experience in analysing large datasets
What You'll Do.
Analyse spatial genomics datasets
Develop methods to call somatic mutations
Integrate transcriptomic profiles
Integrate mutational data
Work with lab members
Collaborate with other teams
Contribute to supervision of students
How You'll Work.
Team & Collaboration
Complementary computational projects; Complementary wet lab projects; Other teams within Institute; Other teams beyond Institute
Communication Scope
Present results to diverse audience
Full Job Description
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges. The [Cellular Genomics Programme ](https://www.sanger.ac.uk/programme/cellular-genomics/)is seeking a Postdoctoral Fellow to work on integrating mutational and spatial transcriptomic datasets in the [Lee-Six group](http://www.sanger.ac.uk/group/lee-six-group/). The group is focused on studying the earliest stages of childhood cancer by investigating the conditions under which cells with particular cancer-driving mutations gain a selective advantage over their healthy neighbours. This position will be for a 2 year fixed term contract. **About the Team:** Henry Lee-Six is a paediatric pathology registrar. His previous work has been focused on somatic mutations in normal tissues. He is starting a new group in the Cellular Genomics Programme with the aim of understanding the interplay between somatic mutations and development in childhood cancer. A major goal of the group is to investigate the relative contribution of mutation identity, cell state, and microenvironmental context in determining whether a mutant cell progresses to form a tumour. The group pursues this line of research by studying samples of children’s tumours and normal tissues with cutting-edge spatial transcriptomic platforms coupled to different mutation-calling technologies such as laser capture microdissection and duplex sequencing. These data are used to build models of what determines a cell’s selective advantage, which are in turn used to identify perturbations to a cell’s state or microenvironment that might change the relative fitness of a mutant clone. These _in silico_ predictions are then tested _in vitro_ using iPSC and cell-line models. The group is a mixture of wet and dry lab researchers and clinicians and collaborates closely with other teams in the Cellular Genomics Programme and the wid
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