ChemicalBiologist

**_Job Family_ :** Scientist ** _Travel Required_ :** None ** _Clearance Required_ :** Ability to Obtain Public Trust ** _What You Will Do_ :** We are currently searching for a Chemical Biologist to provide support services to satisfy the overall operational objectives of the National Heart, Lung, and Blood Institute (NHLBI). This is a full-time, on-site opportunity in Bethesda, MD. * Synthesize and optimize small cyclic peptides for diagnostic imaging and early-stage drug discovery applications. * Design and develop small molecules as chemical tools to support biological research, including target validation and imaging (MRI, optical, PET). * Develop and implement mRNA-based peptide expression systems for cyclic peptide production. * Perform peptide conjugation, including linking to fluorescent dyes, chelators, or imaging agents. * Prepare and characterize antibody fragments (e.g., nanobodies, Fab2) and conjugate them for imaging applications. * Conduct compound screening, synthesis, and optimization workflows. * Utilize modern analytical instrumentation to characterize compounds and ensure quality. * Collaborate closely with multidisciplinary teams in a service-oriented research environment. * Document and communicate experimental results effectively through reports and presentations. **_What You Will Need_ :** * Ph.D. in Chemistry, Biochemistry, or related field with a minimum of TWO (2) years of laboratory research experience OR Master's degree in Chemistry, Biochemistry, or related field with a minimum of FOUR (4) years of laboratory research in lieu of Ph.D. * Demonstrated expertise in cyclic peptide generation, screening, synthesis, and optimization. * Strong background in synthetic chemistry, including small molecule and peptide synthesis. * Knowledge of chemical biology approaches for drug discovery or imaging applications. * Experience with or knowledge of fluorescent dyes, chelators for radioactive metals, MRI agents and nanoparticles. * Must be able to o